General Information
-
DRAMP ID
- DRAMP20880
-
Peptide Name
- DAN2
-
Source
- Monarch butterfly (Danaus plexippus)
-
Family
- Belongs to the cecropin family.
-
Gene
- KGM_210265
-
Sequence
- RWKFLKKIEKVGRKVRDGVIKAGPAVGVVGQATSIYK
-
Sequence Length
- 37
-
UniProt Entry
- A0A212F3T6
-
Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- [Ref.29501691] Gram-positive bacteria: Bacillus subtilis (MIC=50μ±μ19 μg/mL);
- Gram-negative bacteria: Escherichia coli (MIC=2.1μ±μ0.7 μg/mL), Pseudomonas aeruginosa (MIC=5μ±μ2.5 μg/mL), Klebsiella pneumoniae (MIC=4.3μ±μ1.4 μg/mL);
- Fungi: Candida albicans (MIC=72.5μ±μ35.2 μg/mL)
-
Hemolytic Activity
-
- [Ref.29501691] 0% haemolysis at 10 μg/ml, 0% haemolysis at 25 μg/ml, 0% haemolysis at 50 μg/ml, 0% haemolysis at 100 μg/ml, 0% haemolysis at 200 μg/ml against sheep red blood cells
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Random coil
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP20880.
Physicochemical Information
-
Formula
- C188H317N55O46
Absent Amino Acids
- CHMN
Common Amino Acids
- K
Mass
- 4083.93
PI
- 10.77
Basic Residues
- 10
Acidic Residues
- 2
Hydrophobic Residues
- 15
Net Charge
- +8
-
Boman Index
- -5143
Hydrophobicity
- -0.214
Aliphatic Index
- 97.3
Half Life
-
- Mammalian:1 hour
- Yeast:2 min
- E.coli:2 min
Extinction Coefficient Cystines
- 6990
Absorbance 280nm
- 194.17
Polar Residues
- 8
DRAMP20880
Comments Information
Function
- Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity.
Literature Information
- ·Literature 1
-
Title
- Identification and screening of potent antimicrobial peptides in arthropod genomes.
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Pubmed ID
- 29501691
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Reference
- Peptides. 2018 May;103:26-30. doi: 10.1016/j.peptides.2018.01.017.
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Author
- Duwadi D, Shrestha A, Yilma B, Kozlovski I, Sa-Eed M, Dahal N, Jukosky J.