General Information
-
DRAMP ID
- DRAMP20882
-
Peptide Name
- LOUDEF1
-
Source
- Human body louse (Pediculhumanus humanus)
-
Family
- Derived from defensin-like peptides
-
Gene
- 8233460 Phum_PHUM365
-
Sequence
- ATCDLLSASTPWGSLNHSACAAHCLTKRYKGGRCRNGICRCRR
-
Sequence Length
- 43
-
UniProt Entry
- E0VPU4
-
Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Antifungal
-
Target Organism
-
- [Ref.29501691] Gram-positive bacteria: Staphylococcus aureus (MIC=35μ±μ1.3 μg/mL), Bacillus subtilis (MIC=7μ±μ1.6 μg/mL);
- Fungi: Candida albicans (MIC= 19.1μ±μ9.6 μg/mL)
-
Hemolytic Activity
-
- [Ref.29501691] 0% haemolysis at 10 μg/ml, 0% haemolysis at 25 μg/ml, 0% haemolysis at 50 μg/ml, 0% haemolysis at 100 μg/ml, 0% haemolysis at 200 μg/ml against sheep red blood cells
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP20882.
Physicochemical Information
-
Formula
- C192H318N70O56S6
Absent Amino Acids
- EFMQV
Common Amino Acids
- CR
Mass
- 4695.43
PI
- 9.69
Basic Residues
- 10
Acidic Residues
- 1
Hydrophobic Residues
- 11
Net Charge
- +9
-
Boman Index
- -10597
Hydrophobicity
- -0.435
Aliphatic Index
- 56.98
Half Life
-
- Mammalian:4.4 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 7365
Absorbance 280nm
- 175.36
Polar Residues
- 20
DRAMP20882
Comments Information
Function
- Antibacterial activity against the Gram-positive bacteria. Antifungal activity Candida albicans.
Literature Information
- ·Literature 1
-
Title
- Identification and screening of potent antimicrobial peptides in arthropod genomes.
-
Pubmed ID
- 29501691
-
Reference
- Peptides. 2018 May;103:26-30.
-
Author
- Duwadi D, Shrestha A, Yilma B, Kozlovski I, Sa-Eed M, Dahal N, Jukosky J.