General Information

    • DRAMP ID

    • DRAMP20885

    • Peptide Name

    • Hp1404-T1a

    • Source

    • Synthetic construct

    • Family

    • Derived from Hp1404

    • Gene

    • Not found

    • Sequence

    • ILKKLWEGVKSI

    • Sequence Length

    • 12

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • [Ref.29379033] Gram-negative bacteria: Pseudomonas aeruginosa 431 (MIC=25 μM), Pseudomonas aeruginosa 434 (MIC=25 μM), Pseudomonas aeruginosa 3399 (MIC=25 μM), Pseudomonas aeruginosa 3592 (MIC=12.5 μM), Pseudomonas aeruginosa 3904 (MIC=25 μM), Pseudomonas aeruginosa 4891 (MIC=25 μM), Pseudomonas aeruginosa 671973 (MIC=25 μM)

    • Hemolytic Activity

      • [Ref.29379033] Hp1404-T1a does not induce substantial hemolysis, even at the high tested concentration (200μμM) against mouse red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Lipopolysaccharide (LPS)-binding

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • The peptide adopts an alpha-helical conformation in the membrane-mimicking environments and adopts a random coil conformation in the presence of all liposome types .

    • Helical Wheel Diagram

    • DRAMP20885 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20885.

Physicochemical Information

    • Formula

    • C68H116N16O16

    • Absent Amino Acids

    • ACDFHMNPQRTY

    • Common Amino Acids

    • K

    • Mass

    • 1413.77

    • PI

    • 9.7

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +2

    • Boman Index

    • 13

    • Hydrophobicity

    • 0.292

    • Aliphatic Index

    • 154.17

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 500

    • Polar Residues

    • 2

DRAMP20885

Comments Information

    • Function

    • Antibacterial activity against the Gram-negative bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Mechanisms driving the antibacterial and antibiofilm properties of Hp1404 and its analogue peptides against multidrug-resistant Pseudomonas aeruginosa.

    • Reference

    • Sci Rep. 2018 Jan 29;8(1):1763.

    • Author

    • Kim MK, Kang HK, Ko SJ, Hong MJ, Bang JK, Seo CH, Park Y.