General Information
-
DRAMP ID
- DRAMP20892
-
Peptide Name
- H3A/H4A
-
Source
- Synthetic construct
-
Family
- Derived from TP4
-
Gene
- Not found
-
Sequence
- FIAAIIGGLFSAGKAIHRLIRRRRR
-
Sequence Length
- 25
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Antifungal
-
Target Organism
-
- [Ref.29040295] Gram-positive bacteria: Staphylococcus aureus (MIC=32 μg/ml; MBC=32 μg/ml), Methicillin-resistant Staphylococcus aureus (MIC=128 μg/ml; MBC=256 μg/ml);
- Fungi: Candida albicans (MIC=512 μg/ml; MBC=512 μg/ml)
-
Hemolytic Activity
-
- [Ref.29040295] 7% haemolysis at 1.56 μg/ml, 10% haemolysis at 3.13 μg/ml, 70% haemolysis at 6.25 μg/ml, 95% haemolysis at 12.50 μg/ml, 98% haemolysis at 25.00 μg/ml, 100% haemolysis at 50.00 μg/ml against mouse red blood cells
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP20892.
Physicochemical Information
-
Formula
- C129H222N46O27
Absent Amino Acids
- CDEMNPQTVWY
Common Amino Acids
- R
Mass
- 2849.47
PI
- 12.7
Basic Residues
- 8
Acidic Residues
- 0
Hydrophobic Residues
- 13
Net Charge
- +8
-
Boman Index
- -5267
Hydrophobicity
- 0.272
Aliphatic Index
- 125.2
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 4
DRAMP20892
Comments Information
Function
- Antibacterial activity against the Gram-positive bacteria. Antifungal activity.
Literature Information
- ·Literature 1
-
Title
- Hydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4.
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Pubmed ID
- 29040295
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Reference
- PLoS One. 2017 Oct 17;12(10):e0186442.
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Author
- Chang TW, Wei SY, Wang SH, Wei HM, Wang YJ, Wang CF, Chen C, Liao YD.