General Information

    • DRAMP ID

    • DRAMP20896

    • Peptide Name

    • L9A/F10A

    • Source

    • Synthetic construct

    • Family

    • Derived from TP4

    • Gene

    • Not found

    • Sequence

    • FIHHIIGGAASAGKAIHRLIRRRRR

    • Sequence Length

    • 25

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • [Ref.29040295] Fungi: Candida albicans (MIC=128 μg/ml; MBC=128 μg/ml)

    • Hemolytic Activity

      • [Ref.29040295] 5% haemolysis at 25.00 μg/ml, 10% haemolysis at 50.00 μg/ml, 30% haemolysis at 100.00 μg/ml, 95% haemolysis at 200.00 μg/ml, 100% haemolysis at 400.00 μg/ml, 100% haemolysis at 800.00 μg/ml against mouse red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP20896 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20896.

Physicochemical Information

    • Formula

    • C126H216N50O27

    • Absent Amino Acids

    • CDEMNPQTVWY

    • Common Amino Acids

    • R

    • Mass

    • 2863.42

    • PI

    • 12.7

    • Basic Residues

    • 10

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +10

    • Boman Index

    • -6989

    • Hydrophobicity

    • -0.248

    • Aliphatic Index

    • 109.6

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP20896

DRAMP20896 chydropathy plot

Comments Information

    • Function

    • Antifungal activity.

Literature Information

  • ·Literature 1

    • Title

    • Hydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4.

    • Reference

    • PLoS One. 2017 Oct 17;12(10):e0186442.

    • Author

    • Chang TW, Wei SY, Wang SH, Wei HM, Wang YJ, Wang CF, Chen C, Liao YD.