General Information

    • DRAMP ID

    • DRAMP20908

    • Peptide Name

    • Ctry2459-H3 (Ctry2459 peptide derivative, His-rich)

    • Source

    • Synthetic construct(from a scorpion venom peptide library)

    • Family

    • Derived from the peptide Ctry2459

    • Gene

    • Not found

    • Sequence

    • FLHFLHHLF

    • Sequence Length

    • 9

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral

    • Target Organism

      • [Ref.23415044] Virus: Hepatitis C virus ( EC50 = 0.85 μg/ml ).
      • Cytotoxic: Huh7.5.1 cells (CC50>500 μg/ml)

    • Hemolytic Activity

      • [Ref.23415044] HC50 = 416.4 μg/ml against human red blood cells.

    • Cytotoxicity

      • [Ref.23415044] CC50>500 μg/ml against Huh7.5.1 cells

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP20908 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20908.

Physicochemical Information

    • Formula

    • C63H83N15O10

    • Absent Amino Acids

    • ACDEGIKMNPQRSTVWY

    • Common Amino Acids

    • FHL

    • Mass

    • 1210.45

    • PI

    • 7.02

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +3

    • Boman Index

    • 972

    • Hydrophobicity

    • 1.133

    • Aliphatic Index

    • 130

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP20908

Comments Information

    • Function

    • Inhibits hepatitis C virus(HCV) infection via inactivating infectious viral particle. However, it cannot suppress established infection because of the poor cellular uptake and restriction of endosomes.

Literature Information

  • ·Literature 1

    • Title

    • Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus.

    • Reference

    • Biomaterials. 2013 Apr;34(13):3511-22.

    • Author

    • Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z.