• DRAMP ID

    • DRAMP20926
    • Peptide Name

    • IN1(designed based on indolicidin and ranalexin)
    • Source

    • Synthetic construct
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • LLPWKWPWWKWRR
    • Sequence Length

    • 13
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Unknown
    • Biological Activity

    • Antibacterial, Antimicrobial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.26046345] Gram-negative bacteria: Escherichia coli ATCC 25922(MIC=31.25μg/ml), Pseudomonas aeruginosa ATCC 15442(MIC=31.25μg/ml), Acinetobacter baumanii ATCC 15308(MIC>250μg/ml), citrobacter spp(MIC>250μg/ml), Klebsiella pneumoniae(MIC>250μg/ml) ;
      • Gram-positive bacteria: Streptococcus pneumoniae(30 clinical isolates)(MIC=31.25–62.5μg/ml), Staphylococcus aureus ATCC 25923(MIC=31.25μg/ml), Methicillin resistant Staphylococcus aureus (MRSA)(MIC=31.25μg/ml), Enterococcus cloacae(MIC>250μg/ml),
    • Hemolytic activity

      • [Ref.26046345] The hemolytic activities of IN1 is 3.6% at 250μg/ml against human RBCs.
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP20926 helical wheel diagram
    • Formula

    • C101H136N26O14
    • Absent Amino Acids

    • ACDEFGHIMNQSTVY
    • Common Amino Acids

    • W
    • Mass

    • 1938.36
    • PI

    • 12.02
    • Basic Residues

    • 4
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 7
    • Boman Index

    • -1945
    • Hydrophobicity

    • -130
    • Aliphatic Index

    • 60
    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 27500
    • Absorbance 280nm

    • 2291.67
    • Polar Residues

    • 0

DRAMP20926

    • Function

    • Exhibits antimicrobial activity against the Gram-positive and Gram-negative bacteria.
  • Literature 1
    • Reference

    • PLoS One. 2015 Jun 5;10(6):e0128532.
    • Author

    • Jindal HM, Le CF, Mohd Yusof MY, Velayuthan RD, Lee VS, Zain SM, Isa DM, Sekaran SD.
    • Title

    • Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae.