General Information
-
DRAMP ID
- DRAMP20930
-
Peptide Name
- BP100-Ala-NH-C16H33
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- KKLFKKILKYLA
-
Sequence Length
- 12
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- [Ref.29750913] Gram-negative bacteria:Escherichia coli(ATCC 25922)(MIC=16μM);
- Gram-positive bacteria:Staphylococcus aureus (ATCC 25923)(MIC=8μM);Bacillus subtilis(PY79)(MIC=8μM)
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Hemolytic Activity
-
- [Ref.29750913] C50 =6.3μM against human red blood cells
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation and Acylation (-NH-C₁₆H₃₃, conjugated with a n‑hexadecyl acyl chain)
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Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Alpha helix
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP20930.
Physicochemical Information
-
Formula
- C75H129N17O14
Absent Amino Acids
- CDEGHMNPQRSTVW
Common Amino Acids
- K
Mass
- 1492.95
PI
- 10.3
Basic Residues
- 5
Acidic Residues
- 0
Hydrophobic Residues
- 6
Net Charge
- +5
-
Boman Index
- -342
Hydrophobicity
- -0.025
Aliphatic Index
- 138.33
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 1490
Absorbance 280nm
- 135.45
Polar Residues
- 1
DRAMP20930
Comments Information
Function
- Antibacterial activity against the Gram-positive and Gram-negative bacteria.
Literature Information
- ·Literature 1
-
Title
- Synthesis, biophysical and functional studies of two BP101 analogues modified by a hydrophobic chain and a cyclic peptide.
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Pubmed ID
- 29750913
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Reference
- Biochim Biophys Acta. 2018 Aug;1860(8):1502-1516.
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Author
- Carretero GPB, Saraiva GKV, Cauz ACG, Rodrigues MA, Kiyota S, Riske KA, Dos Santos AA, Pinatto-Botelho MF, Bemquerer MP, Gueiros-Filho FJ, Chaimovich H, Schreier S, Cuccovia IM.