General Information

    • DRAMP ID

    • DRAMP20936

    • Peptide Name

    • ΔPb-CATH1

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RVKRFKKFFRKIKKGFRKIFKKTKIFIG

    • Sequence Length

    • 28

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.28630199] Gram-positive bacteria: Staphylococcus aureus (ATCC 29213)(MIC>128 μg/ml); B. cereus ATCC 10876 (MIC=46 μg/ml);
      • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2 μg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=3 μg/ml), S. typhimurium ATCC 14028 (MIC=1.5 μg/ml)

    • Hemolytic Activity

      • [Ref.28630199]1.4 ± 0.4% hemolysis at 8 μg/ml, 5.1 ± 0.5% hemolysis at 16 μg/ml, 7.3 ± 0.6% hemolysis at 32 μg/ml, 12.2 ± 0.7% hemolysis at 64 μg/ml against chicken red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP20936 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20936.

Physicochemical Information

    • Formula

    • C175H290N50O30

    • Absent Amino Acids

    • ACDEHLMNPQSWY

    • Common Amino Acids

    • K

    • Mass

    • 3574.54

    • PI

    • 12.5

    • Basic Residues

    • 14

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +14

    • Boman Index

    • -7427

    • Hydrophobicity

    • -0.696

    • Aliphatic Index

    • 66.07

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP20936

DRAMP20936 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Genomewide Analysis of the Antimicrobial Peptides in Python bivittatus and Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity

    • Reference

    • Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00530-17.

    • Author

    • Kim D, Soundrarajan N, Lee J, Cho HS, Choi M, Cha SY, Ahn B, Jeon H, Le MT, Song H, Kim JH, Park C.