• • DRAMP ID

  • DRAMP20946

• • Peptide Name

  • ΔPb-CATH4 bivittatus antimicrobial peptides peptide derivative

• • Source

  • Synthetic construct

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • TRSRWRRFIRGAGRFARRYGWRIA

• • Sequence Length

  • 24

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic

• • Biological Activity

  • Antimicrobial, Antibacterial

• • Target Organism

  • • [Ref.28630199] Gram-negative bacteria: Escherichia coli (ATCC 25922)(MIC=1μg/ml);Pseudomonas aeruginosa (ATCC 27853)(MIC=3μg/ml);S. typhimurium (ATCC 14028)(MIC=0.5μg/ml);
    • Gram-positive bacteria: Staphylococcus aureus (ATCC 29213)(MIC>128μg/ml);B. cereus (ATCC 10876)(MIC=10μg/ml);
    • Clinical isolates:Escherichia coli(MIC=4.7μg/ml);K. pneumoniae(MIC=1.18μg/ml)

• • Hemolytic Activity

  • • [Ref.28630199]Hemolysis 0% at 4μg/ml against human red blood cell;Hemolysis 1.2 ± 0.3% at 8μg/ml against human red blood cell;Hemolysis 3.2 ± 0.4% at 16μg/ml against human red blood cell;Hemolysis 6.5 ± 0.4% at 32μg/ml against human red blood cell;Hemolysis 10.7 ± 0.2% at 64μg/ml against human red blood cell

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP20946.

DRAMP20946

• • Function

  • Antibacterial activity against the Gram-negative and Gram-negative bacteria. It is tested against the clinically isolated antibiotic resistance strains Escherichia coli and Klebsiella pneumoniae,which showed complete resistance particularly toward ampicillin and to a lesser extent with gentamicin

• ·Literature 1

• • Title

  • Genomewide Analysis of the Antimicrobial Peptides in Python bivittatus and Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity.

• • Pubmed ID

  • 28630199

• • Reference

  • Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00530-17.

• • Author

  • Kim D, Soundrarajan N, Lee J, Cho HS, Choi M, Cha SY, Ahn B, Jeon H, Le MT, Song H, Kim JH, Park C.