General Information
-
DRAMP ID
- DRAMP20948
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Peptide Name
- [K]7-VmCT1-NH2 VmCT1 petide derivative
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Source
- Synthetic construct
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Family
- Belongs to the scorpion NDBP 7 family
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Gene
- Not found
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Sequence
- FLGALWKVAKSVF
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Sequence Length
- 13
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UniProt Entry
- No entry found
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Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
-
- [Ref.27912176] Gram-negative bacteria: Escherichia coli (SBS 363)(MIC=1.56μmol/L);Pseudomonas aeruginosa (ATCC 27853)(MIC=0.39μmol/L);Escherichia coli (D31)(MIC=1.56μmol/L);Serratia marcescens (ATCC 4112)(MIC=0.78μmol/L);Enterobacter cloacae (beta-12)(MIC=6.25μmol/L);
- Gram-positive bacteria: Micrococcus luteus (A270)(MIC=1.56μmol/L);Staphylococcus aureus (ATCC 29213)(MIC=1.56μmol/L);Bacillus subtilis (ATCC 6633)(MIC=3.12μmol/L);Staphylococcus epidermidis (ATCC 12228)(MIC=1.56μmol/L);
- Fungi: Candida albicans MDM8(MIC=1.56μmol/L);Candida tropicalis (IOC 4560)(MIC=1.56μmol/L);Candida parapsilosis (IOC 4564)(MIC=1.56μmol/L);
- Aspergillus niger(MIC=6.25μmol/L);
- Cladosporium herbarum (ATCC 26362)(MIC=12.5μmol/L);
- Cryptococcus neoformans(MIC=1.56μmol/L)
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Hemolytic Activity
-
- [Ref.27912176] MHC=1.60μmol/L against human red blood cells
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
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N-terminal Modification
- Free
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C-terminal Modification
- Amidation
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Nonterminal Modifications and Unusual Amino Acids
- None
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Stereochemistry
- L
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Structure
- Helical structures
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Structure Description
- The peptide adopts Helical fraction 0.04 in water;0.43 in TFE/Water;0.80 in POPC;0.63 in POPC:POPG;0.88 in POPC:DOPE;
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Helical Wheel Diagram
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PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP20948.
Physicochemical Information
-
Formula
- C74H112N16O15
Absent Amino Acids
- CDEHIMNPQRTY
Common Amino Acids
- AFKLV
Mass
- 1465.8
PI
- 10
Basic Residues
- 2
Acidic Residues
- 0
Hydrophobic Residues
- 9
Net Charge
- +2
-
Boman Index
- 1627
Hydrophobicity
- 1.177
Aliphatic Index
- 120
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 458.33
Polar Residues
- 2
DRAMP20948
Comments Information
Function
- Antibacterial activity against the Gram-positive and Gram-negative bacteria and fungi.It presented higher or equivalent antimicrobial activity when compared to VmCT2.
Literature Information
- ·Literature 1
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Title
- Novel designed VmCT1 analogs with increased antimicrobial activity.
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Pubmed ID
- 27912176
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Reference
- Eur J Med Chem. 2017 Jan 27;126:456-463.
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Author
- Pedron CN, Torres MT, Lima JADS, Silva PI, Silva FD, Oliveira VX.