General Information

    • DRAMP ID

    • DRAMP20965

    • Peptide Name

    • LPcin-YK3 (bovine cathelicidin, cattle, ruminant, mammals, animals)

    • Source

    • Bovine Lactophoricin

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • MNKVKEWIKYLKSLFSM

    • Sequence Length

    • 17

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.30021422] Gram-positive bacteria : Streptococcus mutans KCCM 40105 (MIC=1.25 μg/ml), Propionibacteria acnes KCCM 41747 (MIC=1.25 μg/ml), Staphylococcus aureus KCTC 1621 (MIC=0.62 μg/ml);
      • Gram-negative bacteria : Porphyromonas gingvalis KCTC 5352 (MIC=0.62 μg/ml), Escherichia coli KCCM 41290 (MIC=1.25 μg/ml);
      • Fungi : Candida albicans KCTC 17712 (MIC=10.0 μg/ml)

    • Hemolytic Activity

      • [Ref.30021422] 0% hemolysis at 40 μg/ml against mouse red blood cell

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Random coil, alpha helix

    • Structure Description

    • LPcin-YK3 peptide is a random coil in aqueous solution and forms an

    • Helical Wheel Diagram

    • DRAMP20965 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20965.

Physicochemical Information

    • Formula

    • C101H161N23O24S2

    • Absent Amino Acids

    • ACDGHPQRT

    • Common Amino Acids

    • K

    • Mass

    • 2145.65

    • PI

    • 9.82

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +3

    • Boman Index

    • -1378

    • Hydrophobicity

    • -0.206

    • Aliphatic Index

    • 85.88

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 6990

    • Absorbance 280nm

    • 436.88

    • Polar Residues

    • 4

DRAMP20965

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial Activity of Antimicrobial Peptide LPcin-YK3 Derived from Bovine Lactophoricin

    • Reference

    • J Microbiol Biotechnol.?2018 Aug 28;28(8):1299-1309. doi: 10.4014/jmb.1805.05001.

    • Author

    • Ji-Sun Kim,Ji-Ho Jeong, Jang-Hee Cho,Dong-Hee Lee and Yongae Kim