• • DRAMP ID

  • DRAMP20966

• • Peptide Name

  • andricin B (Andrias davidianus, Amphibians, Animals)

• • Source

  • Andrias davidianus

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • GLTRLFSVIK

• • Sequence Length

  • 10

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Not found

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

• • Target Organism

  • • [Ref.29130500]Gram-positive bacteria : Bacillus subtilis CICC 10034 (MIC=32 μg/ml, 33.4 μMol/ml;MBC=32 μg/ml, 33.4 μMol/ml), Staphylococcus aureus CICC10306 (MIC=16 μg/ml, 16.7 μMol/ml;MBC=32 μg/ml, 33.4 μMol/ml), Staphylococcus aureus CICC 10384 (MIC=16 μg/ml, 16.7 μMol/ml;MBC=32 μg/ml, 33.4 μMol/ml), Listeria innocua CICC 10417 (MIC=32 μg/ml, 33.4 μMol/ml;MBC=32 μg/ml, 33.4 μMol/ml);
    • Gram-negative bacteria : Escherichia coli CICC10293 (MIC=16 μg/ml, 16.7 μMol/ml;MBC=32 μg/ml, 33.4 μMol/ml), Pseudomonas aeruginosa CICC 21636 (MIC=8 μg/ml, 8.3 μMol/ml;MBC=16 μg/ml, 16.7 μMol/ml), Serratia marcescens ATCC 4112 (MIC=8 μg/ml, 8.3 μMol/ml;MBC=16 μg/ml, 16.7 μMol/ml), Enterobacter cloacae CICC 21539 (MIC=16 μg/ml, 16.7 μMol/ml;MBC=32 μg/ml, 33.4 μMol/ml), Salmonella paratyphi CICC 10437 (MIC=32 μg/ml, 33.4 μMol/ml;MBC=32 μg/ml, 33.4 μMol/ml);
    • Fungi : Aspergillus niger CICC 2124 (MIC=64 μg/ml, 66.8 μMol/ml;MBC=64 μg/ml, 66.8 μMol/ml), Candida albicans CICC 1965 (MIC=32 μg/ml, 33.4 μMol/ml;MBC=64 μg/ml, 66.8 μMol/ml), Saccharomyces cerevisiae CICC 1002 (MIC=64 μg/ml, 66.8 μMol/ml;MBC=64 μg/ml, 66.8 μMol/ml)

• • Hemolytic Activity

  • • [Ref.29130500] 0% hemolysis at 64 μg/ml , 0.5% hemolysis at 128 μg/ml , 2% hemolysis at 256 μg/ml , 13% hemolysis at 512 μg/ml against human red blood cells

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • Structure

  • Random coil

• • Structure Description

  • The residues Lys and Arg possess the positive charge, and charge-induced folding may influence the structure.

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP20966.

DRAMP20966

• • Function

  • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Saccharomyces cerevisiae, Aspergillus niger

• ·Literature 1

• • Title

  • Purifification, characterization and application of a novel antimicrobial peptide from Andrias davidianus blood

• • Pubmed ID

  • 29130500

• • Reference

  • Lett Appl Microbiol.?2018 Jan;66(1):38-43. doi: 10.1111/lam.12823.

• • Author

  • J. Pei, Z. Feng,T. Ren,H. Sun,H. Han,W. Jin,J. Dang and Y. Tao