General Information

    • DRAMP ID

    • DRAMP20969

    • Peptide Name

    • HJH-1 (bovine cathelicidin, cattle, ruminant, mammals, animals)

    • Source

    • Bovine

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KLLKHKLLVTLA

    • Sequence Length

    • 12

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.30110916]Gram-positive bacteria : Staphylococcus aureus ATCC29213 (MIC=25 μg/ml), Clinical Staphylococcus aureus (MIC=25 μg/ml), ;
      • Gram-negative bacteria : Escherichia coli ATCC25922 (MIC=12.5 μg/ml), Clinical Escherichia coli (MIC=25 μg/ml), Salmonella pullorum CVCC3533 (MIC=6.25 μg/ml), Clinical Salmonella (MIC=6.25 μg/ml);
      • Fungi : Candida albicans ATCC 90029 (MIC=50 μg/ml)

    • Hemolytic Activity

      • [Ref.30110916] 8% hemolysis at 50 μg/ml , 12% hemolysis at 100 μg/ml , 16% hemolysis at 200 μg/ml , 17% hemolysis at 300 μg/ml , 18% hemolysis at 400 μg/ml against rabbit red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP20969 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20969.

Physicochemical Information

    • Formula

    • C66H121N17O14

    • Absent Amino Acids

    • CDEFGIMNPQRSWY

    • Common Amino Acids

    • L

    • Mass

    • 1376.79

    • PI

    • 10.3

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +4

    • Boman Index

    • 657

    • Hydrophobicity

    • 0.783

    • Aliphatic Index

    • 195

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 1

DRAMP20969

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans

Literature Information

  • ·Literature 1

    • Title

    • HJH-1, a Broad-Spectrum Antimicrobial Activity and Low Cytotoxicity Antimicrobial Peptide

    • Reference

    • Molecules. 2018 Aug 14;23(8). pii: E2026. doi: 10.3390/molecules23082026.

    • Author

    • Qing Wang, Yanzhao Xu, Mengmeng Dong, Bolin Hang, Yawei Sun, Lei Wang,Yongqiang Wang, Jianhe Hu, and Wenju Zhang