• • DRAMP ID

  • DRAMP20975

• • Peptide Name

  • OH-CM6 (Derived from OH-CATH30)

• • Source

  • Synthetic construct

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • KFFKKLKKAVKKGFKKFAKV

• • Sequence Length

  • 20

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic form

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.22491685] Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=12.5 μg/ml), Staphylococcuss aureus ATCC 43300 MRSA (MIC=3.125 μg/ml), Staphylococcuss aureus clinical strain 1 (MIC=6.25 μg/ml), Staphylococcuss aureus clinical strain 2 (MIC=3.125 μg/ml), Staphylococcuss aureus clinical strain 3 (MIC=12.5 μg/ml), Enterococcus faecalis ATCC 29212 (MIC=25 μg/ml) ;
    • Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=12.5 μg/ml), Escherichia coli ML-35p (MIC=6.25 μg/ml), Escherichia coli clinical strain 1 (MIC=12.5 μg/ml), Escherichia coli clinical strain 2 (MIC=3.125 μg/ml), Escherichia coli clinical strain 3 (MIC=1.56 μg/ml), Escherichia coli clinical strain 4 (MIC=12.5 μg/ml), Escherichia coli clinical strain 5 (MIC=6.25 μg/ml), Escherichia coli clinical strain 6 (MIC=3.125 μg/ml), Enterobacter cloacae ATCC 13047 (MIC>100 μg/ml), Enterobacter cloacae clinical strain (MIC>100 μg/ml), Enterobacter aerogenes clinical strain (MIC>100 μg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=12.5 μg/ml), Pseudomonas aeruginosa PA 01 (MIC=12.5 μg/ml), Pseudomonas aeruginosa clinical strain 1 (MIC=12.5 μg/ml), Pseudomonas aeruginosa clinical strain 2 (MIC=6.25 μg/ml), Haemophilus influenzae ATCC 49247 (MIC=3.125 μg/ml), Haemophilus influenzae ATCC 49766 (MIC=6.25 μg/ml), Klebsiella pneumoniae ATCC 13883 (MIC=6.25 μg/ml), Klebsiella pneumoniae ATCC 700603 (MIC=3.125 μg/ml) ;
    • Fungi : Candida albicans ATCC 2002 (MIC>200 μg/ml), Candida albicans clinical strain (MIC>200 μg/ml)

• • Hemolytic Activity

  • • [Ref.22491685] 13% hemolysis at 100 μg/ml , 17% hemolysis at 200 μg/ml , 18% hemolysis at 300 μg/ml , 18.5% hemolysis at 400 μg/ml against human red blood cells

• • Cytotoxicity

  • • [Ref.22491685] The cell viability of HaCaT cell lines is 76%, 62% and 53% at peptide concentrations of 50, 100, 200 μg/ml. In Kunming mice, the LD50 of OH-CATH30 is 120 mg/kg for i.p. injection, while those of pexiganan(control 1) and PMB(control 2) are

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP20975.

DRAMP20975

• • Function

  • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans

• ·Literature 1

• • Title

  • Efficacy of OH-CATH30 and Its Analogs against Drug-ResistantBacteria In Vitro and in Mouse Models

• • Pubmed ID

  • 22491685

• • Reference

  • Antimicrob Agents Chemother. 2012 Jun;56(6):3309-17. doi: 10.1128/AAC.06304-11.

• • Author

  • Sheng-An Li, Wen-Hui Lee, and Yun Zhang