General Information

    • DRAMP ID

    • DRAMP20980

    • Peptide Name

    • Anoplin-4 (Derived from Anoplin)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • kllkwwkkll

    • Sequence Length

    • 10

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.25316570]Gram-positive bacteria : Staphylococcus aureus (MIC=8 μg/ml), bacillus subtilis (MIC=4 μg/ml);
      • Gram-negative bacteria : Escherichia coli (MIC=8 μg/ml), Peudomonas eruginosa (MIC=8 μg/ml)

    • Hemolytic Activity

      • [Ref.25316570] 0.5% hemolysis at 12.5 μg/ml , 0.5% hemolysis at 25 μg/ml , 2% hemolysis at 50 μg/ml , 1% hemolysis at 100 μg/ml , 4% hemolysis at 200 μg/ml against mice red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • D

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP20980 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20980.

Physicochemical Information

    • Formula

    • C70H114N16O11

    • Absent Amino Acids

    • ACDEFGHIMNPQRSTVY

    • Common Amino Acids

    • KL

    • Mass

    • 1355.78

    • PI

    • 10.48

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +4

    • Boman Index

    • 214

    • Hydrophobicity

    • -0.22

    • Aliphatic Index

    • 156

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 1222.22

    • Polar Residues

    • 0

DRAMP20980

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria

Literature Information

  • ·Literature 1

    • Title

    • Design of novel analogues of short antimicrobial peptide anoplin with improved antimicrobial activity

    • Reference

    • J Pept Sci. 2014 Dec;20(12):945-51. doi: 10.1002/psc.2705.

    • Author

    • Yang Wang, Jianbo Chen, Xin Zheng, Xiaoli Yang, Panpan Ma,Ying Cai,Bangzhi Zhangb,and Yuan Chen