• • DRAMP ID

  • DRAMP20987

• • Peptide Name

  • CPF-6 (Derived from CPF-C1)

• • Source

  • Synthetic construct

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • lFwKLLlKAlrLwAkVL

• • Sequence Length

  • 17

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic form

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.28371431]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=8 μg/ml), Staphylococcuss aureus 725 (MIC=8 μg/ml), Staphylococcuss aureus 794 (MIC=16 μg/ml), Staphylococcuss aureus 936 (MIC=8 μg/ml);
    • Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=16 μg/ml), Escherichia coli 780 (MIC=16 μg/ml), Escherichia coli 804 (MIC=16 μg/ml), Escherichia coli 850 (MIC=16 μg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=16 μg/ml), Pseudomonas aeruginosa 2760 (MIC=16 μg/ml), Pseudomonas aeruginosa 9132 (MIC=64 μg/ml), Acinetobacter baumannii ATCC 19606 (MIC=8 μg/ml), Acinetobacter baumannii 1980 (MIC8=μg/ml), Acinetobacter baumannii 2982 (MIC=8 μg/ml), Acinetobacter baumannii 4956 (MIC=8 μg/ml)

• • Hemolytic Activity

  • • [Ref.28371431] 0% hemolysis at 4 μg/ml , 3% hemolysis at 8 μg/ml , 17.5% hemolysis at 16 μg/ml , 45% hemolysis at 32 μg/ml , 70% hemolysis at 64 μg/ml , 80% hemolysis at 128 μg/ml , 85% hemolysis at 256 μg/ml , 90% hemolysis at 512 μg/ml against human red blood cells

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • Mixed(D-Leu1, D-Trp3, D-Leu7, D-Leu10, D-Arg11, D-Trp13, D-Lys15)

• • Structure

  • Random coil

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP20987.

DRAMP20987

• • Function

  • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria

• ·Literature 1

• • Title

  • Novel Antimicrobial Peptide CPF-C1 Analogs with Superior Stabilities and Activities against Multidrug-Resistant Bacteria

• • Pubmed ID

  • 28371431

• • Reference

  • Chem Biol Drug Des. 2017 Nov;90(5):690-702. doi: 10.1111/cbdd.12988.

• • Author

  • Junqiu Xie,Qian Zhao,Sisi Li,Zhibin Yan,Jing Li,Yao Li,Lingyun Mou,Bangzhi Zhang,Wenle Yang,Xiaokang Miao,Xianxing Jiang,and Rui Wang