General Information
-
DRAMP ID
- DRAMP20991
-
Peptide Name
- CPF-10 (Derived from CPF-C1)
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- wFwKLLwKAlrLwWkVL
-
Sequence Length
- 17
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic form
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- [Ref.28371431]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=8 μg/ml), Staphylococcuss aureus 725 (MIC=16 μg/ml), Staphylococcuss aureus 794 (MIC=16 μg/ml), Staphylococcuss aureus 936 (MIC=8 μg/ml);
- Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=16 μg/ml), Escherichia coli 780 (MIC=16 μg/ml), Escherichia coli 804 (MIC=32 μg/ml), Escherichia coli 850 (MIC=16 μg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=32 μg/ml), Pseudomonas aeruginosa 2760 (MIC=16 μg/ml), Pseudomonas aeruginosa 9132 (MIC=256 μg/ml), Acinetobacter baumannii ATCC 19606 (MIC=16 μg/ml), Acinetobacter baumannii 1980 (MIC=16 μg/ml), Acinetobacter baumannii 2982 (MIC=16 μg/ml), Acinetobacter baumannii 4956 (MIC=16 μg/ml)
-
Hemolytic Activity
-
- [Ref.28371431]0% hemolysis at 4 μg/ml , 5% hemolysis at 8 μg/ml , 21% hemolysis at 16 μg/ml , 40% hemolysis at 32 μg/ml , 56% hemolysis at 64 μg/ml , 65% hemolysis at 128 μg/ml , 73% hemolysis at 256 μg/ml , 85% hemolysis at 512 μg/ml against human red blood cells
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- Mixed(D-Trp1, D-Trp3, D-Trp7, D-Leu10, D-Arg11, D-Trp13, D-Lys15)
-
Structure
- Random coil
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP20991.
Physicochemical Information
-
Formula
- C64H89N13O4
Absent Amino Acids
- CDEGHIMNPQRSTY
Common Amino Acids
- L
Mass
- 2372.98
PI
- 11.26
Basic Residues
- 2
Acidic Residues
- 0
Hydrophobic Residues
- 8
Net Charge
- +2
-
Boman Index
- 1974
Hydrophobicity
- 0.9
Aliphatic Index
- 114.71
Half Life
-
- Mammalian:
- Yeast:
- E.coli:
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 343.75
Polar Residues
- 0
DRAMP20991
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria
Literature Information
- ·Literature 1
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Title
- Novel Antimicrobial Peptide CPF-C1 Analogs with Superior Stabilities and Activities against Multidrug-Resistant Bacteria
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Pubmed ID
- 28371431
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Reference
- Chem Biol Drug Des. 2017 Nov;90(5):690-702. doi: 10.1111/cbdd.12988.
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Author
- Junqiu Xie,Qian Zhao,Sisi Li,Zhibin Yan,Jing Li,Yao Li,Lingyun Mou,Bangzhi Zhang,Wenle Yang,Xiaokang Miao,Xianxing Jiang,and Rui Wang