General Information

    • DRAMP ID

    • DRAMP20996

    • Peptide Name

    • anoplin analog 6

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RLLKFIKKLL

    • Sequence Length

    • 10

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.27862650]Gram-positive bacteria : Mycobacteria smegmatis mc2 155 (MIC=20 μg/ml), Bacillus subtilis DELTA (MIC=40 μg/ml);
      • Gram-negative bacteria : Escherichia coli DH5a (MIC=400 μg/ml), Zymomonas mobilis 10988 (MIC=10 μg/ml);
      • Fungi : Candida parapsilosis (MIC=30 μg/ml)

    • Hemolytic Activity

      • [Ref.27862650]0% hemolysis at 300 μg/ml , 3% hemolysis at 400 μg/ml , 12% hemolysis at 500 μg/ml against human red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP20996 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20996.

Physicochemical Information

    • Formula

    • C63H114N16O11

    • Absent Amino Acids

    • ACDEGHMNPQSTVWY

    • Common Amino Acids

    • L

    • Mass

    • 1271.7

    • PI

    • 11.26

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +4

    • Boman Index

    • -399

    • Hydrophobicity

    • 0.63

    • Aliphatic Index

    • 195

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP20996

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida parapsilosis

Literature Information

  • ·Literature 1

    • Title

    • Synthesis and biological activity of lipophilic analogs of the cationic antimicrobial active peptide anoplin

    • Reference

    • J Pept Sci. 2016 Nov;22(11-12):731-736. doi: 10.1002/psc.2939.

    • Author

    • Kostas Chionis, Dimitrios Krikorian, Anna-Irini Koukkou, Maria Sakarellos-Daitsiotis and Eugenia Panou-Pomonis