General Information

    • DRAMP ID

    • DRAMP20999

    • Peptide Name

    • anoplin analog 9

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLLKFIKKLL

    • Sequence Length

    • 10

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.27862650]Gram-positive bacteria : Mycobacteria smegmatis mc2 155 (MIC=5 μg/ml);
      • Gram-negative bacteria : Escherichia coli DH5a (MIC=40 μg/ml), Pseudomonas aeruginosa PAO (MIC=5 μg/ml), Zymomonas mobilis 10988 (MIC=30 μg/ml)

    • Hemolytic Activity

      • [Ref.27862650]10% hemolysis at 50 μg/ml , 12% hemolysis at 100 μg/ml , 10% hemolysis at 400 μg/ml , 11% hemolysis at 500 μg/ml against human red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Acylation (Conjugated with dodecanoic acid)

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP20999 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20999.

Physicochemical Information

    • Formula

    • C59H105N13O11

    • Absent Amino Acids

    • ACDEHMNPQRSTVWY

    • Common Amino Acids

    • L

    • Mass

    • 1172.56

    • PI

    • 10.3

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +3

    • Boman Index

    • 1187

    • Hydrophobicity

    • 1.04

    • Aliphatic Index

    • 195

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 1

DRAMP20999

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria

Literature Information

  • ·Literature 1

    • Title

    • Synthesis and biological activity of lipophilic analogs of the cationic antimicrobial active peptide anoplin

    • Reference

    • J Pept Sci. 2016 Nov;22(11-12):731-736. doi: 10.1002/psc.2939.

    • Author

    • Kostas Chionis, Dimitrios Krikorian, Anna-Irini Koukkou, Maria Sakarellos-Daitsiotis and Eugenia Panou-Pomonis