General Information

    • DRAMP ID

    • DRAMP21018

    • Peptide Name

    • A (I17R) (Derived from AR-23)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • AIGSILGALAKGLPTLRSWIKNR

    • Sequence Length

    • 23

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.27271216]Gram-positive bacteria : Staphylococcuss aureus (MIC=25 μM), Staphylococcus epidermidis (MIC=6.25 μM), Bacillus subtilis (MIC=3.13 μM);
      • Gram-negative bacteria : Escherichia coli (MIC=12.5 μM), Pseudomonas aeruginosa (MIC=12.5 μM), Klebsiella pneumoniae (MIC=25 μM)

    • Hemolytic Activity

      • [Ref.27271216] 10% hemolysis at 20 μM , 15% hemolysis at 40 μM , 20% hemolysis at 60 μM , 30% hemolysis at 80 μM , 35% hemolysis at 100 μM against human red blood cells

    • Cytotoxicity

      • [Ref.27271216] In L929 cells, the cell viability is 85%, 68%, 21% and 6.6% at peptide concentrations of 6.25, 12.5, 25 and 50 μM.

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21018 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21018.

Physicochemical Information

    • Formula

    • C111H191N33O28

    • Absent Amino Acids

    • CDEFHMQVY

    • Common Amino Acids

    • L

    • Mass

    • 2435.94

    • PI

    • 12.02

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +4

    • Boman Index

    • -1193

    • Hydrophobicity

    • 0.339

    • Aliphatic Index

    • 131.74

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 250

    • Polar Residues

    • 7

DRAMP21018

DRAMP21018 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria

Literature Information

  • ·Literature 1

    • Title

    • Design of an α-helical antimicrobial peptide with improved cell selective and potent anti-biofilm activity

    • Reference

    • Sci Rep. 2016 Jun 8;6:27394. doi: 10.1038/srep27394.

    • Author

    • Shi-KunZhang, Jin-wen Song, FengGong, Su-Bo Li, Hong-Yu Chang, Hui-MinXie, Hong-WeiGao, Ying-XiaTan & Shou-Ping Ji