General Information
-
DRAMP ID
- DRAMP21024
-
Peptide Name
- Stigmurin (Tityus, Scorpionida, Arachnida)
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Source
- Scorpion Tityus stigmurus
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Family
- Not found
-
Gene
- Not found
-
Sequence
- FFSLIPSLVGGLISAFK
-
Sequence Length
- 17
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- [Ref.30709056]Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC=9.4 μM), Staphylococcus epidermidis (ATCC 12228)(MIC=9.4 μM), Enterococcus faecalis (ATCC 4028)(MIC>150 μM);
- Gram-negative bacteria : Pseudomonas aeruginosa (ATCC 27853)(MIC>150 μM), Escherichia coli (ATCC 25922)(MIC>150 μM), Enterobacter cloacae (ATCC 13047)(MIC>150 μM);
- Fungi : Candida albicans (ATCC 90028)(MIC=37.5 μM), Candida glabrata (ATCC 90030)(MIC>150 μM), Candida krusei (ATCC 6258)(MIC>150 μM)
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Hemolytic Activity
-
- [Ref.30709056] 7% hemolysis at 1.2 μg/ml , 4% hemolysis at 2.3 μg/ml , 2% hemolysis at 4.7 μg/ml , 0% hemolysis at 9.4 μg/ml , 3% hemolysis at 18.8 μg/ml , 2% hemolysis at 37.5 μg/ml , 3% hemolysis at 75 μg/ml , 5% hemolysis at 150 μg/ml against human red blood cells
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Alpha helix
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP21024.
Physicochemical Information
-
Formula
- C89H138N18O21
Absent Amino Acids
- CDEHMNQRTWY
Common Amino Acids
- FLS
Mass
- 1796.18
PI
- 8.75
Basic Residues
- 1
Acidic Residues
- 0
Hydrophobic Residues
- 10
Net Charge
- +1
-
Boman Index
- 2552
Hydrophobicity
- 1.535
Aliphatic Index
- 137.65
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 5
DRAMP21024
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Candida glabrata, Candida krusei
Literature Information
- ·Literature 1
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Title
- Potent and Broad-Spectrum Antimicrobial Activity of Analogs from the Scorpion Peptide Stigmurin
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Pubmed ID
- 30709056
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Reference
- Int J Mol Sci. 2019 Jan 31;20(3). pii: E623. doi: 10.3390/ijms20030623.
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Author
- Bruno Amorim-Carmo , Alessandra Daniele-Silva , Adriana M. S. Parente ,Allanny A. Furtado , Eneas Carvalho , Johny W. F. Oliveira , Elizabeth C. G. Santos , Marcelo S. Silva , Sérgio R. B. Silva , Arnóbio A. Silva-Júnior , Norberto K. Monteiro and Matheus F. Fernandes-Pedrosa