General Information

    • DRAMP ID

    • DRAMP21028

    • Peptide Name

    • L10, 11-DPS3 (Derived from dermaseptin-PS3 (DPS3))

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • ALWKDILKNLLKAALNEINQIVQ

    • Sequence Length

    • 23

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.30087268]Gram-positive bacteria : Staphylococcuss aureus (NCTC 10788)(MIC=8 μM);
      • Gram-negative bacteria : Escherichia coli (NCTC 10418)(MIC=16 μM);
      • Fungi : Candida albicans (NCYC 1467)(MIC=16 μM)

    • Hemolytic Activity

      • [Ref.30087268] 20% hemolysis at 0 μM , 70% hemolysis at 1 μM , 95% hemolysis at 2 μM against horse red blood cells

    • Cytotoxicity

      • [Ref.30087268] IC50 = 0.12 μM for H157.
      • IC50 = 1.85 μM for PC3.
      • IC50 = 8.76 μM for HMEC-1

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Random coil, alpha helix

    • Structure Description

    • These three peptides existed in random coils in aqueous solution, they all adopted

    • Helical Wheel Diagram

    • DRAMP21028 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21028.

Physicochemical Information

    • Formula

    • C122H206N32O33

    • Absent Amino Acids

    • CFGHMPRSTY

    • Common Amino Acids

    • L

    • Mass

    • 2649.17

    • PI

    • 8.54

    • Basic Residues

    • 3

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +1

    • Boman Index

    • -1202

    • Hydrophobicity

    • 0.217

    • Aliphatic Index

    • 161.3

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 250

    • Polar Residues

    • 3

DRAMP21028

DRAMP21028 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans

Literature Information

  • ·Literature 1

    • Title

    • Yining Tan ,Xiaoling Chen , Chengbang Ma , Xinping Xi ,Lei Wang , Mei Zhou ,James F. Burrows ,Hang Fai Kwok 2 ID and Tianbao Chen

    • Reference

    • Toxins (Basel). 2018 Aug 7;10(8). pii: E320. doi: 10.3390/toxins10080320.

    • Author

    • Yining Tan ,Xiaoling Chen , Chengbang Ma , Xinping Xi ,Lei Wang , Mei Zhou ,James F. Burrows ,Hang Fai Kwok 2 ID and Tianbao Chen