General Information
-
DRAMP ID
- DRAMP21030
-
Peptide Name
- D5r (Derived from HD5)
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- ATYrTGrATrESLSGVEISGrLYrLR
-
Sequence Length
- 26
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic form
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
-
Target Organism
-
- [Ref.26206286]Gram-positive bacteria : Staphylococcus aureus (NCTC 8530)(MIC=100 μM), Bacillus subtilis (NCIM 2162)(MIC=50 μM);
- Gram-negative bacteria : Escherichia coli (MG 1655)(MIC=50 μM), Pseudomonas aeruginosa (NCTC 6750)(MIC=200 μM);
- Fungi : Candida albicans (ATCC 18804)(MIC=20 μM)
-
Hemolytic Activity
-
- [Ref.26206286] 0% hemolysis at 100μM against human red blood cells
-
Cytotoxicity
-
- [Ref.26206286] No cytotoxic information found.
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- Mixed(D-Arg4, D-Arg7, D-Arg10, D-Arg21, D-Arg24)
-
Structure
- Alpha helix, beta sheet, beta turn
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP21030.
Physicochemical Information
-
Formula
- C96H144N24O29
Absent Amino Acids
- CDFHKMNPQW
Common Amino Acids
- GLST
Mass
- 2969.36
PI
- 11.34
Basic Residues
- 1
Acidic Residues
- 2
Hydrophobic Residues
- 7
Net Charge
- -1
-
Boman Index
- -1657
Hydrophobicity
- 0.15
Aliphatic Index
- 78.85
Half Life
-
- Mammalian:4.4 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 2980
Absorbance 280nm
- 119.2
Polar Residues
- 11
DRAMP21030
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans
Literature Information
- ·Literature 1
-
Title
- Antimicrobial activity of human-defensin 5 and its linear analogs: N-terminal fatty acylation results in enhanced antimicrobial activity of the linear analogs
-
Pubmed ID
- 26206286
-
Reference
- Peptides. 2015 Sep;71:128-40. doi: 10.1016/j.peptides.2015.07.009. Epub 2015 Jul 20.
-
Author
- Basil Mathew Ramakrishnan Nagaraj