General Information

    • DRAMP ID

    • DRAMP21031

    • Peptide Name

    • MyD5R (Derived from HD5)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • ATYRTGRATRESLSGVEISGRLYRLR

    • Sequence Length

    • 26

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.26206286]Gram-positive bacteria : Staphylococcus aureus (NCTC 8530)(MIC=7.5 μM), Bacillus subtilis (NCIM 2162)(MIC=20 μM);
      • Gram-negative bacteria : Escherichia coli (MG 1655)(MIC=5 μM), Pseudomonas aeruginosa (NCTC 6750)(MIC=10 μM);
      • Fungi : Candida albicans (ATCC 18804)(MIC=10 μM), Saccharomyces cerevisiae (BY4741)(MIC=20 μM)

    • Hemolytic Activity

      • [Ref.26206286] 23% hemolysis at 10 μM , 50% hemolysis at 20 μM , 75% hemolysis at 50 μM , 87.5% hemolysis at 100 μM against human red blood cells

    • Cytotoxicity

      • [Ref.26206286] No cytotoxic information found.

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Acylation (Conjugated with myristic acid)

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix, beta sheet, beta turn

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21031 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21031.

Physicochemical Information

    • Formula

    • C126H214N44O39

    • Absent Amino Acids

    • CDFHKMNPQW

    • Common Amino Acids

    • R

    • Mass

    • 2969.36

    • PI

    • 11.34

    • Basic Residues

    • 6

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +4

    • Boman Index

    • -9117

    • Hydrophobicity

    • -0.715

    • Aliphatic Index

    • 78.85

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 2980

    • Absorbance 280nm

    • 119.2

    • Polar Residues

    • 11

DRAMP21031

DRAMP21031 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Saccharomyces cerevisiae

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial activity of human-defensin 5 and its linear analogs: N-terminal fatty acylation results in enhanced antimicrobial activity of the linear analogs

    • Reference

    • Peptides. 2015 Sep;71:128-40. doi: 10.1016/j.peptides.2015.07.009. Epub 2015 Jul 20.

    • Author

    • Basil Mathew Ramakrishnan Nagaraj