General Information

    • DRAMP ID

    • DRAMP21035

    • Peptide Name

    • AC-UM-14W (De novo synthesis)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KAAKAAKKAAKAAWK

    • Sequence Length

    • 15

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.26235946]Gram-positive bacteria : Bacillus subtilis (MIC>200 μg/ml), Staphylococcus aureus (MIC>200 μg/ml), Staphylococcus epidermis (MIC>200 μg/ml);
      • Gram-negative bacteria : Escherichia coli (MIC>200 μg/ml), Shigella dysentariae (MIC>200 μg/ml), Salmonella typhimurium (MIC>200 μg/ml), Klebsiella pneumonia (MIC>200 μg/ml), Pseudomonas aeruginosa (MIC>200 μg/ml)

    • Hemolytic Activity

      • [Ref.26235946] <1% hemolysis at 12.5 μM , <1% hemolysis at 25 μM against human red blood cells

    • Cytotoxicity

      • [Ref.26235946] No cytotoxic information found.

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Acylation (Conjugated with acetyl group)

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21035 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21035.

Physicochemical Information

    • Formula

    • C71H124N22O16

    • Absent Amino Acids

    • CDEFGHILMNPQRSTVY

    • Common Amino Acids

    • A

    • Mass

    • 1541.9

    • PI

    • 10.7

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +6

    • Boman Index

    • -1649

    • Hydrophobicity

    • -0.66

    • Aliphatic Index

    • 53.33

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 392.86

    • Polar Residues

    • 0

DRAMP21035

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial activity of doubly-stapled alanine/lysine-based peptides

    • Reference

    • Bioorg Med Chem Lett. 2015 Sep 15;25(18):4016-9. doi: 10.1016/j.bmcl.2015.06.053.

    • Author

    • Thuy T. T. Dinh , Do-Hee Kim , Huy X. Luong , Bong-Jin Lee , Young-Woo Kim