General Information

    • DRAMP ID

    • DRAMP21039

    • Peptide Name

    • analog 2 (Derived from Ib-AMP2)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • WGRRGWGpGRRYVRN

    • Sequence Length

    • 15

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.19778562] Gram-positive bacteria : Bacillus subtilis(KCTC 3068)(MIC=4

    • Hemolytic Activity

      • [Ref.19778562] MHC>400

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • Mixed(D-Pro8)

    • Structure

    • Random coil, beta turn

    • Structure Description

    • In sodium phosphate buffer, the CD spectra of Ib-AMP1 and all linear analogs showed a large absorbance in the region of 190-200 nm, indicating a random coil structure. The spectra of Ib-AMP1 and analogs 1, 2, 3, and 4 became significantly more b-turn in 30 mM SDS micelles

    • Helical Wheel Diagram

    • DRAMP21039 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21039.

Physicochemical Information

    • Formula

    • C78H116N32O16

    • Absent Amino Acids

    • ACDEFHIKLMPQST

    • Common Amino Acids

    • R

    • Mass

    • 1873.12

    • PI

    • 12.18

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +5

    • Boman Index

    • -6892

    • Hydrophobicity

    • -1.767

    • Aliphatic Index

    • 19.33

    • Half Life

      • Mammalian:2.8 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 12490

    • Absorbance 280nm

    • 892.14

    • Polar Residues

    • 6

DRAMP21039

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial specificity and mechanism of action of disulfide-removed linear analogs of the plant-derived Cys-rich antimicrobial peptide Ib-AMP1

    • Reference

    • Peptides.?2009 Dec;30(12):2144-9. doi: 10.1016/j.peptides.2009.09.020.

    • Author

    • Peng Wang , Jeong-Kyu Bang , Hak Jun Kim , Jin-Kyoung Kim , Yangmee Kim , Song Yub Shin