General Information
-
DRAMP ID
- DRAMP21044
-
Peptide Name
- A4 (Derived from Indolicidin (IN))
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- ILKWKWKWWPWRR
-
Sequence Length
- 13
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic form
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- [Ref.19428758] Gram-positive bacteria : Bacillus subtilis(MIC=10 μg/ml), Staphylococcus epidermidis(MIC=10 μg/ml), Staphylococcus aureus(MIC=10 μg/ml);
- Gram-negative bacteria : Escherichia coli(MIC=10 μg/ml), Pseudomonas aeruginosa(MIC=10 μg/ml), Salmonella typhimurium(MIC=10 μg/ml)
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Hemolytic Activity
-
- [Ref.19428758] HC50=560 μg/ml against human red blood cells
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
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C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP21044.
Physicochemical Information
-
Formula
- C102H141N27O14
Absent Amino Acids
- ACDEFGHMNQSTVY
Common Amino Acids
- W
Mass
- 1969.41
PI
- 12.02
Basic Residues
- 5
Acidic Residues
- 0
Hydrophobic Residues
- 7
Net Charge
- +5
-
Boman Index
- -2500
Hydrophobicity
- -1.423
Aliphatic Index
- 60
Half Life
-
- Mammalian:20 hour
- Yeast:30 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 27500
Absorbance 280nm
- 2291.67
Polar Residues
- 0
DRAMP21044
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria
Literature Information
- ·Literature 1
-
Title
- Design of novel indolicidin-derived antimicrobial peptides with enhanced cell specificity and potent anti-inflammatory activity
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Pubmed ID
- 19428758
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Reference
- Peptides. 2009 May;30(5):832-8. doi: 10.1016/j.peptides.2009.01.015.
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Author
- Yong Hai Nan , Jeong-Kyu Bang , Song Yub Shin