General Information

    • DRAMP ID

    • DRAMP21047

    • Peptide Name

    • A7 (Derived from Indolicidin (IN))

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • ILKWKWKWWKWRR

    • Sequence Length

    • 13

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.19428758] Gram-positive bacteria : Bacillus subtilis(MIC=5 μg/ml), Staphylococcus epidermidis(MIC=10 μg/ml), Staphylococcus aureus(MIC=5 μg/ml);
      • Gram-negative bacteria : Escherichia coli(MIC=10 μg/ml), Pseudomonas aeruginosa(MIC=10 μg/ml), Salmonella typhimurium(MIC=5 μg/ml)

    • Hemolytic Activity

      • [Ref.19428758] HC50>800 μg/ml against human red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21047 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21047.

Physicochemical Information

    • Formula

    • C103H146N28O14

    • Absent Amino Acids

    • ACDEFGHMNPQSTVY

    • Common Amino Acids

    • W

    • Mass

    • 2000.47

    • PI

    • 12.03

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +6

    • Boman Index

    • -3055

    • Hydrophobicity

    • -1.6

    • Aliphatic Index

    • 60

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 27500

    • Absorbance 280nm

    • 2291.67

    • Polar Residues

    • 0

DRAMP21047

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria

Literature Information

  • ·Literature 1

    • Title

    • Design of novel indolicidin-derived antimicrobial peptides with enhanced cell specificity and potent anti-inflammatory activity

    • Reference

    • Peptides. 2009 May;30(5):832-8. doi: 10.1016/j.peptides.2009.01.015.

    • Author

    • Yong Hai Nan , Jeong-Kyu Bang , Song Yub Shin