General Information

    • DRAMP ID

    • DRAMP21049

    • Peptide Name

    • peptide 6.2 (Derived from seq2)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLLRKWGKKWKEFLRRVWK

    • Sequence Length

    • 19

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.28236791] Gram-positive bacteria : Staphylococcus aureus(MIC=32 μg/ml);
      • Gram-negative bacteria : Pseudomonas aeruginosa(MIC=32 μg/ml)

    • Hemolytic Activity

      • [Ref.28236791] 34.46% hemolysis at 128 μg/ml

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • The spectra obtained confirmed an alpha-helix conversion in the presence of negatively charged micelles.

    • Helical Wheel Diagram

    • DRAMP21049 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21049.

Physicochemical Information

    • Formula

    • C122H192N36O22

    • Absent Amino Acids

    • ACDHIMNPQSTY

    • Common Amino Acids

    • K

    • Mass

    • 2515.09

    • PI

    • 11.75

    • Basic Residues

    • 8

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +7

    • Boman Index

    • -4867

    • Hydrophobicity

    • -1.137

    • Aliphatic Index

    • 76.84

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 16500

    • Absorbance 280nm

    • 916.67

    • Polar Residues

    • 2

DRAMP21049

DRAMP21049 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria

Literature Information

  • ·Literature 1

    • Title

    • Lipid selectivity in novel antimicrobial peptides: Implication on antimicrobial and hemolytic activity

    • Reference

    • Colloids Surf B Biointerfaces. 2017 May 1;153:152-159. doi: 10.1016/j.colsurfb.2017.02.003.

    • Author

    • P. Maturanaa, M. Martinez , M.E. Noguerac, N.C. Santos , E.A. Disalvoa, L. Semorile , P.C. Maffia , A. Hollmann