• • DRAMP ID

  • DRAMP21082

• • Peptide Name

  • ccTP 3 (Derived from TP2)

• • Source

  • Synthetic construct

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • KWCFCVCYRGICRCRCRG

• • Sequence Length

  • 18

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic form

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

• • Target Organism

  • • [Ref.10673369] Gram-positive bacteria : Staphylococcus aureus(MIC=1.3 μM(low-salt);MIC=0.9 μM(high-salt)), Micrococcus luteus(MIC=0.5 μM(low-salt);MIC=0.5 μM(high-salt)), Enterococcus faecalis(MIC=1.9 μM(low-salt);MIC=1.3 μM(high-salt));
    • Gram-negative bacteria : Escherichia coli(MIC=10.4 μM(low-salt);MIC=0.9 μM(high-salt)), Pseudomonas aeruginosa(MIC=6.2 μM(low-salt);MIC=10.4 μM(high-salt)), Primula vulgaris(MIC=16.4 μM(low-salt);MIC=28.9 μM(high-salt)), Klebsiella oxytoca(MIC=4.0 μM(low-salt);MIC=7.6 μM(high-salt));
    • Fungi : Candida albicans(MIC=24.2 μM(low-salt);MIC=30.2 μM(high-salt)), Candida kefyr(MIC=1.1 μM(low-salt);MIC=4.3 μM(high-salt)), Candida tropicalis(MIC=12.4 μM(low-salt);MIC=3.9 μM(high-salt))

• • Hemolytic Activity

  • • [Ref.10673369] EC25=590 μM against human red blood cells

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Cyclic

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

  • Disulfide bonds between Cys3 and Cys16, Cys5 and Cys14, Cys7 and Cys12.

• • Stereochemistry

  • L

• • Structure

  • Beta tile

• • Structure Description

  • Although there is insufficient information to deconvolute these CD spectra of these two-b-strand cyclic cystine-knot structures due to the various contributions by

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP21082.

DRAMP21082

• • Function

  • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Candida kefyr, Candida tropicalis

• ·Literature 1

• • Title

  • Marked Increase in Membranolytic Selectivity of Novel Cyclic Tachyplesins Constrained with an Antiparallel Two-b Strand Cystine Knot Framework

• • Pubmed ID

  • 10673369

• • Reference

  • Biochem Biophys Res Commun. 2000 Jan 27;267(3):783-90.

• • Author

  • James P. Tam, Yi-An Lu, and Jin-Long Yang