• DRAMP ID

    • DRAMP21086
    • Peptide Name

    • PR-FO (Derived from PRW4)
    • Source

    • Synthetic construct
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • RFRRLRWKTRWRLKKIRFGRFLRKIRRFRPK
    • Sequence Length

    • 31
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Unknown
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.25818457] Gram-positive bacteria : Staphylococcus aureus 25923(MIC=8.6 mg/L), Staphylococcus aureus 29213(MIC=4.3 mg/L), Staphylococcus epidermidis 12228(MIC=2.2 mg/L), Enterococcus faecalis 29212(MIC=1.1 mg/L), Bacillus subtilis 11060(MIC=2.2 mg/L);
      • Gram-negative bacteria : Escherichia coli 078(MIC=2.2 mg/L), Escherichia coli K88(MIC=4.3 mg/L), Escherichia coli ER2566(MIC=2.2 mg/L), Escherichia coli 44102(MIC=8.6 mg/L), Escherichia coli 1515(MIC=2.2 mg/L), Escherichia coli 25922(MIC=2.2 mg/L), Escherichia coli UB1005(MIC=4.3 mg/L), Salmonella typhimurium 7731(MIC=0.5 mg/L), Salmonella typhimurium 1402(MIC=8.6 mg/L), Pseudomonas aeruginosa 21625(MIC=8.6 mg/L), Pseudomonas aeruginosa 21630(MIC=0.5 mg/L), Pseudomonas aeruginosa 10419(MIC=4.3 mg/L), Pseudomonas aeruginosa 27853(MIC=8.6 mg/L), Salmonella pullorum 7913(MIC=8.6 mg/L)
    • Hemolytic activity

      • [Ref.25818457] 0% hemolysis at 9.2 mg/L , 1% hemolysis at 18.4 mg/L , 4% hemolysis at 36.8mg/L , 5% hemolysis at 73.6 mg/L , 10% hemolysis at 147.1 mg/L , 13% hemolysis at 294.3 mg/L against human red blood cells
    • Binding Target

    • Unknown
    • Structure

    • Random coil, alpha helix, beta Sheet
    • Structure Description

    • Unknown
    • DRAMP21086 helical wheel diagram
    • Formula

    • C201H334N74O33
    • Absent Amino Acids

    • ACDEHMNQSVY
    • Common Amino Acids

    • R
    • Mass

    • 4315.34
    • PI

    • 13.04
    • Basic Residues

    • 17
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 11
    • Boman Index

    • -16724
    • Hydrophobicity

    • -149.68
    • Aliphatic Index

    • 62.9
    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 11000
    • Absorbance 280nm

    • 366.67
    • Polar Residues

    • 2

DRAMP21086

DRAMP21086 chydropathy plot
    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria
  • Literature 1
    • Reference

    • Biomaterials. 2015 Jun;52:517-30. doi: 10.1016/j.biomaterials.2015.02.063.
    • Author

    • Zhi Ma, Dandan Wei, Ping Yan, Xin Zhu, Anshan Shan , Zhongpeng Bi
    • Title

    • Characterization of cell selectivity, physiological stability and endotoxin neutralization capabilities of a-helix-based peptide amphiphiles