General Information

    • DRAMP ID

    • DRAMP21091

    • Peptide Name

    • I4 (Derived from PRW4)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RFRRLRIKTRIRLKKI

    • Sequence Length

    • 16

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.25735802] Gram-positive bacteria : Staphylococcus aureus 29213(MIC=64 μM), Staphylococcus epidermidis 12228(MIC=16 μM), Enterococcus faecalis 29212(MIC=16 μM);
      • Gram-negative bacteria : Escherichia coli 25922(MIC=8 μM), Escherichia coli 1005(MIC=16 μM), Salmonella typhimurium 7731(MIC=16 μM)

    • Hemolytic Activity

      • [Ref.25735802] MHC5>256 μM against human red blood cells

    • Cytotoxicity

      • [Ref.25735802] The peptide exhibited no cytoxicity against HaCaT cells in the range of 0/25-256 μM.

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21091 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21091.

Physicochemical Information

    • Formula

    • C97H181N37O18

    • Absent Amino Acids

    • ACDEGHMNPQSVWY

    • Common Amino Acids

    • R

    • Mass

    • 2153.74

    • PI

    • 12.7

    • Basic Residues

    • 9

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +9

    • Boman Index

    • -8116

    • Hydrophobicity

    • -0.969

    • Aliphatic Index

    • 121.88

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 1

DRAMP21091

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria

Literature Information

  • ·Literature 1

    • Title

    • Characterization of antimicrobial activity and mechanisms of low amphipathic peptides with different α-helical propensity

    • Reference

    • Acta Biomater. 2015 May;18:155-67. doi: 10.1016/j.actbio.2015.02.023.

    • Author

    • Xin Zhu, Licong Zhang, Jue Wang, Zhi Ma, Wei Xu, Jianping Li, Anshan Shan