• DRAMP ID

    • DRAMP21096
    • Peptide Name

    • IR2 (Derived from PG-1)
    • Source

    • Synthetic construct
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • IRIRCRRRFCRIRI
    • Sequence Length

    • 14
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Unknown
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.24621994] Gram-positive bacteria : Staphylococcus aureus(MIC=4 μM), Staphylococcus epidermidis(MIC=4 μM), Streptococcus faecalis(MIC=4 μM), Bacillus subtilis(MIC=2 μM);
      • Gram-negative bacteria : Escherichia coli(MIC=1 μM), Salmonella pullorum(MIC=1 μM), Salmonella typhimurium(MIC=4 μM), Bacteriump yocyaneum(MIC=4 μM)
    • Hemolytic activity

      • [Ref.24621994] MHC10=128 μM against human red blood cells
    • Binding Target

    • Unknown
    • Structure

    • Beta sheet, beta hairpin
    • Structure Description

    • Unknown
    • DRAMP21096 helical wheel diagram
    • Formula

    • C81H149N35O15S2
    • Absent Amino Acids

    • ADEGHKLMNPQSTVWY
    • Common Amino Acids

    • R
    • Mass

    • 1917.42
    • PI

    • 12.13
    • Basic Residues

    • 7
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 5
    • Boman Index

    • -7922
    • Hydrophobicity

    • -40.71
    • Aliphatic Index

    • 111.43
    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 9.62
    • Polar Residues

    • 2

DRAMP21096

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria
  • Literature 1
    • Reference

    • PLoS One. 2014 Mar 12;9(3):e91007. doi: 10.1371/journal.pone.0091007.
    • Author

    • Na Dong , Xin Zhu , Shuli Chou , Anshan Shan , Weizhong Li , Junguang Jiang
    • Title

    • Antimicrobial potency and selectivity of simplified symmetric-end peptides