General Information
-
DRAMP ID
- DRAMP21096
-
Peptide Name
- IR2 (Derived from PG-1)
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- IRIRCRRRFCRIRI
-
Sequence Length
- 14
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic form
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
-
Target Organism
-
- [Ref.24621994] Gram-positive bacteria : Staphylococcus aureus(MIC=4 μM), Staphylococcus epidermidis(MIC=4 μM), Streptococcus faecalis(MIC=4 μM), Bacillus subtilis(MIC=2 μM);
- Gram-negative bacteria : Escherichia coli(MIC=1 μM), Salmonella pullorum(MIC=1 μM), Salmonella typhimurium(MIC=4 μM), Bacteriump yocyaneum(MIC=4 μM)
-
Hemolytic Activity
-
- [Ref.24621994] MHC10=128 μM against human red blood cells
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Beta sheet, beta hairpin
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP21096.
Physicochemical Information
-
Formula
- C81H149N35O15S2
Absent Amino Acids
- ADEGHKLMNPQSTVWY
Common Amino Acids
- R
Mass
- 1917.42
PI
- 12.13
Basic Residues
- 7
Acidic Residues
- 0
Hydrophobic Residues
- 5
Net Charge
- +7
-
Boman Index
- -7922
Hydrophobicity
- -0.407
Aliphatic Index
- 111.43
Half Life
-
- Mammalian:20 hour
- Yeast:30 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 9.62
Polar Residues
- 2
DRAMP21096
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria
Literature Information
- ·Literature 1
-
Title
- Antimicrobial potency and selectivity of simplified symmetric-end peptides
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Pubmed ID
- 24621994
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Reference
- PLoS One. 2014 Mar 12;9(3):e91007. doi: 10.1371/journal.pone.0091007.
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Author
- Na Dong , Xin Zhu , Shuli Chou , Anshan Shan , Weizhong Li , Junguang Jiang