General Information

    • DRAMP ID

    • DRAMP21097

    • Peptide Name

    • FR1 (Derived from PG-1)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FRCRRRFCRF

    • Sequence Length

    • 10

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.24621994] Gram-positive bacteria : Staphylococcus aureus(MIC=32 μM), Staphylococcus epidermidis(MIC=16 μM), Streptococcus faecalis(MIC=32 μM), Bacillus subtilis(MIC=4 μM);
      • Gram-negative bacteria : Escherichia coli(MIC=4 μM), Salmonella pullorum(MIC=16 μM), Salmonella typhimurium(MIC=32 μM), Bacteriump yocyaneum(MIC>128 μM)

    • Hemolytic Activity

      • [Ref.24621994] MHC10>128 μM against human red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21097 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21097.

Physicochemical Information

    • Formula

    • C63H99N25O11S2

    • Absent Amino Acids

    • ADEGHIKLMNPQSTVWY

    • Common Amino Acids

    • R

    • Mass

    • 1446.76

    • PI

    • 11.83

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +5

    • Boman Index

    • -6310

    • Hydrophobicity

    • -0.91

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 13.89

    • Polar Residues

    • 2

DRAMP21097

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial potency and selectivity of simplified symmetric-end peptides

    • Reference

    • PLoS One. 2014 Mar 12;9(3):e91007. doi: 10.1371/journal.pone.0091007.

    • Author

    • Na Dong , Xin Zhu , Shuli Chou , Anshan Shan , Weizhong Li , Junguang Jiang