General Information

    • DRAMP ID

    • DRAMP21104

    • Peptide Name

    • Feleucin-2 (toads, amphibians, animals)

    • Source

    • Bombina variegata (Yellow-bellied toad)

    • Family

    • Belongs to the bombinin family.

    • Gene

    • feleucin-2

    • Sequence

    • GIGGALLNVGKVALKGLAKGLAEHFAN

    • Sequence Length

    • 27

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.25003126] Gram-positive bacteria : Staphylococcus aureus(MIC=8 mg/L, MBC=32 mg/L);
      • Gram-negative bacteria : Escherichia coli(MIC=32 mg/L, MBC=32 mg/L);
      • Fungi : Candida albicans(MIC=32 mg/L, MBC=32 mg/L)

    • Hemolytic Activity

      • [Ref.25003126] 100% hemolysis at 64 mg/L against horse red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21104 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21104.

Physicochemical Information

    • Formula

    • C119H200N34O32

    • Absent Amino Acids

    • CDMPQRSTWY

    • Common Amino Acids

    • G

    • Mass

    • 2619.11

    • PI

    • 9.7

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 14

    • Net Charge

    • +3

    • Boman Index

    • 1387

    • Hydrophobicity

    • 0.589

    • Aliphatic Index

    • 126.67

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 8

DRAMP21104

DRAMP21104 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans

Literature Information

  • ·Literature 1

    • Title

    • Feleucins: Novel Bombinin Precursor-Encoded Nonapeptide Amides from the Skin Secretion of Bombina variegata

    • Reference

    • Biomed Res Int. 2014;2014:671362. doi: 10.1155/2014/671362.

    • Author

    • Bing Bai, Xiaojuan Hou, Lei Wang, Lilin Ge, Yu Luo, Chengbang Ma, Mei Zhou, Jinao Duan, Tianbao Chen, and Chris Shaw