General Information

    • DRAMP ID

    • DRAMP21108

    • Peptide Name

    • Feleucin-K3 (Derived from Feleucin-BO1)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FLKLLKKLL

    • Sequence Length

    • 9

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.25056849] Gram-positive bacteria : Staphylococcus aureus(MIC=34 μM, MBC=128 μM)

    • Hemolytic Activity

      • [Ref.25056849] 100% hemolysis at >250 mg/L against horse red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • In F-K3, these latter residues are substituted with Lys (K) residues, whose side-chains occupied the same positions, producing a model cationic amphipathic character in this analogue.

    • Helical Wheel Diagram

    • DRAMP21108 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21108.

Physicochemical Information

    • Formula

    • C57H102N12O10

    • Absent Amino Acids

    • ACDEGHIMNPQRSTVWY

    • Common Amino Acids

    • L

    • Mass

    • 1115.51

    • PI

    • 10.3

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +3

    • Boman Index

    • 1093

    • Hydrophobicity

    • 1.122

    • Aliphatic Index

    • 216.67

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP21108

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria

Literature Information

  • ·Literature 1

    • Title

    • Feleucin-BO1: A Novel Antimicrobial Non-Apeptide Amide from the Skin Secretion of the Toad, Bombina orientalis, and Design of a Potent Broad-Spectrum Synthetic Analogue, Feleucin-K3

    • Reference

    • Chem Biol Drug Des. 2015 Mar;85(3):259-67. doi: 10.1111/cbdd.12396.

    • Author

    • Xiaojuan Hou, Qiang Du, Renjie Li, Mei Zhou, Hui Wang2, Lei Wang2, Can Guo, Tianbao Chen and Chris Shaw