General Information

    • DRAMP ID

    • DRAMP21109

    • Peptide Name

    • FPA-Bombinin-BO (toads, amphibians, animals)

    • Source

    • Asian bombinid toad species, Bombina orientalis

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GIGGALLSAKAALGLAKGLAEHFAN

    • Sequence Length

    • 25

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.25056849] Gram-positive bacteria : Staphylococcus aureus(MIC=7 μM, MBC=14 μM);
      • Gram-negative bacteria : Escherichia coli(MIC=14 μM, MBC=14 μM);
      • Fungi : Candida albicans(MIC=7 μM, MBC=14 μM)

    • Hemolytic Activity

      • [Ref.25056849] 100% hemolysis at 125 mg/L against horse red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21109 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21109.

Physicochemical Information

    • Formula

    • C106H176N30O30

    • Absent Amino Acids

    • CDMPQRTVWY

    • Common Amino Acids

    • A

    • Mass

    • 2350.75

    • PI

    • 8.6

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 14

    • Net Charge

    • +2

    • Boman Index

    • 1726

    • Hydrophobicity

    • 0.724

    • Aliphatic Index

    • 121.6

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 7

DRAMP21109

DRAMP21109 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans

Literature Information

  • ·Literature 1

    • Title

    • Feleucin-BO1: A Novel Antimicrobial Non-Apeptide Amide from the Skin Secretion of the Toad, Bombina orientalis, and Design of a Potent Broad-Spectrum Synthetic Analogue, Feleucin-K3

    • Reference

    • Chem Biol Drug Des. 2015 Mar;85(3):259-67. doi: 10.1111/cbdd.12396.

    • Author

    • Xiaojuan Hou, Qiang Du, Renjie Li, Mei Zhou, Hui Wang, Lei Wang, Can Guo, Tianbao Chen and Chris Shaw