General Information

    • DRAMP ID

    • DRAMP21112

    • Peptide Name

    • DLSA (Derived from SLZP)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • LRRllRWlRRLLRR

    • Sequence Length

    • 14

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.25069749] Gram-positive bacteria : Staphylococcus aureus (ATCC 25923)(MIC=3.15 μg/ml), Bacillus cereus(MIC=3.15 μg/ml);
      • Gram-negative bacteria : E. coli (ATCC 9637)(MIC=12.5 μg/ml), Pseudomonas aeruginosa (ATCC BAA-427)(MIC=12.5 μg/ml), Klebsiella pneumoniae (ATCC 27736)(MIC=6.25 μg/ml);
      • Fungi : Sporothrix schenckii(MIC=6.25 μg/ml), Trichophyton mentagrophytes(MIC=12.5 μg/ml), Aspergillus fumigatus(MIC=6.25 μg/ml), Candida parapsilosis (ATCC 22019)(MIC=12.5 μg/ml)

    • Hemolytic Activity

      • [Ref.25069749] 0% hemolysis at 80 μg/ml against human red blood cells

    • Cytotoxicity

      • [Ref.25069749] The cell viability of murine fibroblast cells (3T3) is 84.8%, 83.4%, 76.9%, 72.1% and 62.8% at peptide concentrations of 1.5, 3, 4.5, 6 and 9 μM.

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • Mixed(4, 5, 8 is D)

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21112 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21112.

Physicochemical Information

    • Formula

    • C71H123N33O9

    • Absent Amino Acids

    • ACDEFGHIKMNPQSTVY

    • Common Amino Acids

    • R

    • Mass

    • 1976.5

    • PI

    • 12.78

    • Basic Residues

    • 7

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +7

    • Boman Index

    • -8735

    • Hydrophobicity

    • -1.5

    • Aliphatic Index

    • 83.57

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 423.08

    • Polar Residues

    • 0

DRAMP21112

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Sporothrix schenckii, Trichophyton mentagrophytes, Aspergillus fumigatus, Candida parapsilosis

Literature Information

  • ·Literature 1

    • Title

    • Design and characterization of short antimicrobial peptides using leucine zipper templates with selectivity towards microorganisms

    • Reference

    • Amino Acids. 2014 Nov;46(11):2531-43. doi: 10.1007/s00726-014-1802-3.

    • Author

    • Ahmad A, Azmi S, Srivastava S, Kumar A, Tripathi JK, Mishra NN, Shukla PK, Ghosh JK