General Information
-
DRAMP ID
- DRAMP21114
-
Peptide Name
- V6S (Derived from tachyplesin I)
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- KWCFRSCYRGICYRRCR
-
Sequence Length
- 17
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic form
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
-
Target Organism
-
- [Ref.26549611] Gram-positive bacteria : Staphylococcus aureus 209P(MIC=6.25 μM);
- Gram-negative bacteria : Escherichia coli C600(MIC=1.56 μM), Pseudomonas aeruginosa PAO1(MIC=12.5 μM)
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Hemolytic Activity
-
- [Ref.26549611] MHC2=280 μM against human red blood cells
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP21114.
Physicochemical Information
-
Formula
- C97H150N34O21S4
Absent Amino Acids
- ADEHLMNPQTV
Common Amino Acids
- R
Mass
- 2256.71
PI
- 9.93
Basic Residues
- 6
Acidic Residues
- 0
Hydrophobic Residues
- 3
Net Charge
- +6
-
Boman Index
- -6754
Hydrophobicity
- -0.812
Aliphatic Index
- 22.94
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 8730
Absorbance 280nm
- 545.63
Polar Residues
- 8
DRAMP21114
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria
Literature Information
- ·Literature 1
-
Title
- Improved strategy for recombinant production and purification of antimicrobial peptide tachyplesin I and its analogs with high cell selectivity.
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Pubmed ID
- 26549611
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Reference
- Biotechnol Appl Biochem. 2017 Jan;64(1):35-42. doi: 10.1002/bab.1456.
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Author
- Panteleev PV, Ovchinnikova TV