General Information

    • DRAMP ID

    • DRAMP21115

    • Peptide Name

    • V6R (Derived from tachyplesin I)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KWCFRRCYRGICYRRCR

    • Sequence Length

    • 17

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.26549611] Gram-positive bacteria : Staphylococcus aureus 209P(MIC>50 μM);
      • Gram-negative bacteria : Escherichia coli C600(MIC=1.56 μM), Pseudomonas aeruginosa PAO1(MIC>50 μM)

    • Hemolytic Activity

      • [Ref.26549611] MHC2=200 μM against human red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21115 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21115.

Physicochemical Information

    • Formula

    • C100H157N37O20S4

    • Absent Amino Acids

    • ADEHLMNPQSTV

    • Common Amino Acids

    • R

    • Mass

    • 2325.82

    • PI

    • 10.33

    • Basic Residues

    • 7

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +7

    • Boman Index

    • -7906

    • Hydrophobicity

    • -1.029

    • Aliphatic Index

    • 22.94

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 8730

    • Absorbance 280nm

    • 545.63

    • Polar Residues

    • 7

DRAMP21115

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria

Literature Information

  • ·Literature 1

    • Title

    • Improved strategy for recombinant production and purification of antimicrobial peptide tachyplesin I and its analogs with high cell selectivity.

    • Reference

    • Biotechnol Appl Biochem. 2017 Jan;64(1):35-42. doi: 10.1002/bab.1456.

    • Author

    • Panteleev PV, Ovchinnikova TV