General Information

    • DRAMP ID

    • DRAMP21127

    • Peptide Name

    • T9K (Derived from RI16)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RFRRLRKKKRKRLKKI

    • Sequence Length

    • 16

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.25494332] Gram-positive bacteria : Staphylococcus aureus 29213(MIC=128 μM), Staphylococcus epidermidis 12228(MIC=128 μM), ;
      • Gram-negative bacteria : Escherichia coli 25922(MIC=128 μM), Salmonella typhimurium 7731(MIC=256 μM), Pseudomonas aeruginosa 27853(MIC=128 μM), Pseudomonas aeruginosa 10419(MIC=256 μM), Pseudomonas aeruginosa 21625(MIC=256 μM), Pseudomonas aeruginosa 21630(MIC=256 μM), Pseudomonas aeruginosa LC(MIC=256 μM), Pseudomonas aeruginosa LCCI(MIC=256 μM), Pseudomonas aeruginosa LCGE(MIC=256 μM), Pseudomonas aeruginosa LCCE(MIC=256 μM)

    • Hemolytic Activity

      • [Ref.25494332] HC50>256 μM against human red blood cells

    • Cytotoxicity

      • [Ref.25494332] The LD50 of J774.1 macrophage cells is larger than 256 μM

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21127 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21127.

Physicochemical Information

    • Formula

    • C99H188N40O17

    • Absent Amino Acids

    • ACDEGHMNPQSTVWY

    • Common Amino Acids

    • KR

    • Mass

    • 2210.84

    • PI

    • 12.71

    • Basic Residues

    • 12

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +12

    • Boman Index

    • -10508

    • Hydrophobicity

    • -2.219

    • Aliphatic Index

    • 73.13

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP21127

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria

Literature Information

  • ·Literature 1

    • Title

    • Importance of Tryptophan in Transforming an Amphipathic Peptide into a Pseudomonas aeruginosa-Targeted Antimicrobial Peptide.

    • Reference

    • PLoS One. 2014 Dec 10;9(12):e114605. doi: 10.1371/journal.pone.0114605.

    • Author

    • Zhu X, Ma Z, Wang J, Chou S, Shan A