General Information
-
DRAMP ID
- DRAMP21137
-
Peptide Name
- GNU5 (De novo synthesis)
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- RVVRPVVQVVKQKVR
-
Sequence Length
- 15
-
UniProt Entry
- No entry found
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Protein Existence
- Synthetic form
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- [Ref.23946320] Gram-positive bacteria : Bacillus subtilis(MIC=16 mg/L), Enterococcus faecalis(MIC=8 mg/L), Micrococcus luteus(MIC=2 mg/L), Staphylococcus aureus(MIC=4 mg/L);
- Gram-negative bacteria : Escherichia coli(MIC=32 mg/L), Pseudomonas aeruginosa(MIC=8 mg/L), Salmonella typhimurium(MIC>64 mg/L);
- Fungi : Candida albicans(MIC=2 mg/L), Cryptococcus neoformans(MIC=2 mg/L), Saccharomyces cerevisiae(MIC=2 mg/L)
-
Hemolytic Activity
-
- [Ref.23946320] 0% hemolysis at 140 mg/L against human red blood cells
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Cytotoxicity
-
- [Ref.23946320] The cell viability of hPBMCs is at peptide concentrations of 4, 8, 16, 32, 64 μg/ml
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Alpha helix
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP21137.
Physicochemical Information
-
Formula
- C80H148N28O18
Absent Amino Acids
- ACDEFGHILMNSTWY
Common Amino Acids
- V
Mass
- 1790.23
PI
- 12.31
Basic Residues
- 5
Acidic Residues
- 0
Hydrophobic Residues
- 7
Net Charge
- +5
-
Boman Index
- -3866
Hydrophobicity
- -0.033
Aliphatic Index
- 135.33
Half Life
-
- Mammalian:1 hour
- Yeast:2 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 0
DRAMP21137
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Cryptococcus neoformans, Saccharomyces cerevisiae
Literature Information
- ·Literature 1
-
Title
- De novo generation of short antimicrobial peptides with enhanced stability and cell specificity
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Pubmed ID
- 23946320
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Reference
- J Antimicrob Chemother. 2014 Jan;69(1):121-32. doi: 10.1093/jac/dkt322.
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Author
- Hyun Kim, Ju Hye Jang, Sun Chang Kim and Ju Hyun Cho