• DRAMP ID

    • DRAMP21166
    • Peptide Name

    • HYL-12 (Derived from HYL)
    • Source

    • Synthetic construct
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • GILSSLLKKLKKIIAK
    • Sequence Length

    • 16
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Unknown
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-gram+, Anti-gram-, Antifungal
    • Target Organism

      • [Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=16 μM), Staphylococcus epidermidis(MIC=1.8 μM);
      • Gram-negative bacteria : Escherichia coli(MIC=8 μM), Pseudomonas aeruginosa 5482(MIC=5 μM);
      • Fungi : Candida albicans(MIC=10 μM)
    • Hemolytic activity

      • [Ref.26998557] LC50=284 μM against human red blood cells
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP21166 helical wheel diagram
    • Formula

    • C83H157N21O19
    • Absent Amino Acids

    • CDEFHMNPQRTVWY
    • Common Amino Acids

    • K
    • Mass

    • 1753.29
    • PI

    • 10.6
    • Basic Residues

    • 5
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 8
    • Boman Index

    • 264
    • Hydrophobicity

    • 56.25
    • Aliphatic Index

    • 176.88
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 3

DRAMP21166

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans
  • Literature 1
    • Reference

    • J Nat Prod. 2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.
    • Author

    • Nešuta O, Hexnerová R, Buděšínský M, Slaninová J, Bednárová L, Hadravová R, Straka J, Veverka V, Čeřovský V
    • Title

    • Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.