General Information
-
DRAMP ID
- DRAMP21169
-
Peptide Name
- HYL-16 (Derived from HYL)
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- GILSKLLKKLKKIIAK
-
Sequence Length
- 16
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic form
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- [Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=23 μM), Staphylococcus epidermidis(MIC=1.8 μM);
- Gram-negative bacteria : Escherichia coli(MIC=18 μM), Pseudomonas aeruginosa 5482(MIC=4.5 μM);
- Fungi : Candida albicans(MIC=45 μM)
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Hemolytic Activity
-
- [Ref.26998557] LC50>400 μM against human red blood cells
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP21169.
Physicochemical Information
-
Formula
- C86H164N22O18
Absent Amino Acids
- CDEFHMNPQRTVWY
Common Amino Acids
- K
Mass
- 1794.38
PI
- 10.7
Basic Residues
- 6
Acidic Residues
- 0
Hydrophobic Residues
- 8
Net Charge
- +7
-
Boman Index
- 49
Hydrophobicity
- 0.369
Aliphatic Index
- 176.88
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 2
DRAMP21169
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans
Literature Information
- ·Literature 1
-
Title
- Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
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Pubmed ID
- 26998557
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Reference
- J Nat Prod. 2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.
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Author
- Nešuta O, Hexnerová R, Buděšínský M, Slaninová J, Bednárová L, Hadravová R, Straka J, Veverka V, Čeřovský V