General Information

    • DRAMP ID

    • DRAMP21170

    • Peptide Name

    • HYL-17 (Derived from HYL)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • kILSSLLKKLKKIIAK

    • Sequence Length

    • 16

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=32 μM), Staphylococcus epidermidis(MIC=1.4 μM);
      • Gram-negative bacteria : Escherichia coli(MIC=16 μM), Pseudomonas aeruginosa 5482(MIC=5 μM);
      • Fungi : Candida albicans(MIC=25 μM)

    • Hemolytic Activity

      • [Ref.26998557] LC50=364 μM against human red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • Mixed(1 is D)

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21170 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21170.

Physicochemical Information

    • Formula

    • C6H-16N2O-13

    • Absent Amino Acids

    • ACDEFGHILMNPQRSTV

    • Common Amino Acids

    • K

    • Mass

    • 1824.41

    • PI

    • 10.7

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 0

    • Net Charge

    • +6

    • Boman Index

    • -555

    • Hydrophobicity

    • -0.244

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP21170

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.

    • Reference

    • J Nat Prod. 2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.

    • Author

    • Nešuta O, Hexnerová R, Buděšínský M, Slaninová J, Bednárová L, Hadravová R, Straka J, Veverka V, Čeřovský V