General Information
-
DRAMP ID
- DRAMP21172
-
Peptide Name
- HYL-19 (Derived from HYL)
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- GILSSWLKKLKKIIAK
-
Sequence Length
- 16
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic form
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- [Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=16 μM), Staphylococcus epidermidis(MIC=2 μM);
- Gram-negative bacteria : Escherichia coli(MIC=11 μM), Pseudomonas aeruginosa 5482(MIC=4 μM);
- Fungi : Candida albicans(MIC=17 μM)
-
Hemolytic Activity
-
- [Ref.26998557] LC50>400 μM against human red blood cells
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP21172.
Physicochemical Information
-
Formula
- C88H156N22O19
Absent Amino Acids
- CDEFHMNPQRTVY
Common Amino Acids
- K
Mass
- 1826.34
PI
- 10.6
Basic Residues
- 5
Acidic Residues
- 0
Hydrophobic Residues
- 8
Net Charge
- +6
-
Boman Index
- 5
Hydrophobicity
- 0.269
Aliphatic Index
- 152.5
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 366.67
Polar Residues
- 3
DRAMP21172
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans
Literature Information
- ·Literature 1
-
Title
- Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
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Pubmed ID
- 26998557
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Reference
- J Nat Prod. 2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.
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Author
- Nešuta O, Hexnerová R, Buděšínský M, Slaninová J, Bednárová L, Hadravová R, Straka J, Veverka V, Čeřovský V