• • DRAMP ID

  • DRAMP21181

• • Peptide Name

  • WR1 (Derived from leucocin A)

• • Source

  • Synthetic construct

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • WGRAFSAGVHRLANGGNG

• • Sequence Length

  • 18

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic form

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

• • Target Organism

  • • [Ref.28002968] Gram-positive bacteria : Staphylococcus aureus 29213(MIC>70.09s μM), Staphylococcus aureus 1.160(MIC=70.09 μM), Listeria monocytogenes 21662(MIC>70.09 μM), Listeria monocytogenes 21633(MIC>70.09 μM), Bacillus cereus 63301(MIC>70.09 μM), Micrococcus luteus 28001(MIC>70.09 μM), Bacillus pumilus 63202(MIC>70.09 μM), Pseudomonas fluorescens 21620(MIC>70.09 μM), MRSA 43300(MIC>70.09 μM);
    • Gram-negative bacteria : Escherichia coli O157 : H7 21530(MIC>70.09 μM), Escherichia coli 25922(MIC>70.09 μM), Escherichia coli 35150(MIC>70.09 μM), Salmonella paratyphi-A 20501(MIC>70.09 μM), Salmonella paratyphi paratyphi-B 21495(MIC>70.09 μM), Salmonella paratyphi paratyphi-C 21512(MIC>70.09 μM), Shigella flexneri 51571(MIC>70.09 μM), Salmonella choleraesuis 13312(MIC>70.09 μM), Salmonella typhimurium 51005(MIC>70.09 μM), Salmonella enteritidis 21527(MIC>70.09 μM), Vibrio parahemolyticus 21617(MIC>70.09 μM);
    • Fungi : Candida albicans 10231(MIC>70.09 μM)

• • Hemolytic Activity

  • • [Ref.28002968] MHC10>70.09 μM against human red blood cells

• • Cytotoxicity

  • • [Ref.28002968] The cell viability of RAW264.7 cells induced by WR1 is 99.44%, 96.62%, 95.21%, 94.08%, 92.96%, 92.99%, 92.68%, 87.04% and 77.58% at peptide concentrations of 0.25, 0.5, 1, 2, 4, 8, 16, 32 and 64 μM.

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • Structure

  • Random coil, alpha helix, beta sheet, turn

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP21181.

DRAMP21181

• • Function

  • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans

• ·Literature 1

• • Title

  • Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical PeptideAmphiphiles.

• • Pubmed ID

  • 28002968

• • Reference

  • J Med Chem. 2016 Dec 22;59(24):10946-10962. doi: 10.1021/acs.jmedchem.6b00922.

• • Author

  • Ma Z, Yang J, Han J, Gao L, Liu H, Lu Z, Zhao H, Bie X