General Information
-
DRAMP ID
- DRAMP21191
-
Peptide Name
- GW-Q6 (De novo synthesis)
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- GIKIAKKAITIAKKIAKIYW
-
Sequence Length
- 20
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic form
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
-
Target Organism
-
- [Ref.18586467] Gram-positive bacteria : Staphylococcus aureus (BCRC 10780)(MIC=32 μg/ml), Staphylococcus xylosus (BCRC 12930)(MIC=4 μg/ml), Staphylococcus aureus (BCRC 10781)(MIC=32 μg/ml), Listeria monocytogenes (BCRC 14845)(MIC=32 μg/ml), Streptococcus bovis (BCRC 14729)(MIC=128 μg/ml), Streptococcus iniae (laboratory strain)(MIC=128 μg/ml), Lactococcus garvieae (laboratory strain)(MIC=128 μg/ml);
- Gram-negative bacteria : Klebsiella oxytoca (BCRC 13985)(MIC=32 μg/ml), Pseudomonas aeruginosa (BCRC 10944)(MIC=16 μg/ml), Escherichia coli (BCRC 10675)(MIC=16 μg/ml), Enterobacter aerogenes (BCRC 10370)(MIC=16 μg/ml), Enterobacter cloacae (BCRC 10401)(MIC=8 μg/ml), Yersinia enterocolitica (BCRC 13999)(MIC=32 μg/ml)
-
Hemolytic Activity
-
- [Ref.18586467] MHC=128 μM against human red blood cells
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP21191.
Physicochemical Information
-
Formula
- C110H189N27O23
Absent Amino Acids
- CDEFHLMNPQRSV
Common Amino Acids
- IK
Mass
- 2257.88
PI
- 10.4
Basic Residues
- 6
Acidic Residues
- 0
Hydrophobic Residues
- 11
Net Charge
- +6
-
Boman Index
- 402
Hydrophobicity
- 0.375
Aliphatic Index
- 137
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 6990
Absorbance 280nm
- 367.89
Polar Residues
- 3
DRAMP21191
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria
Literature Information
- ·Literature 1
-
Title
- Design and synthesis of cationic antimicrobial peptides with improved activity and selectivity against Vibrio spp.
-
Pubmed ID
- 18586467
-
Reference
- Int J Antimicrob Agents. 2008 Aug;32(2):130-8. doi: 10.1016/j.ijantimicag.2008.04.003.
-
Author
- Chou HT, Kuo TY, Chiang JC, Pei MJ, Yang WT, Yu HC, Lin SB, Chen WJ