General Information

    • DRAMP ID

    • DRAMP21192

    • Peptide Name

    • GW-A1 (De novo synthesis)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GAKYAKYIYNFYKYIAKYIW

    • Sequence Length

    • 20

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.18586467] Gram-positive bacteria : Staphylococcus aureus (BCRC 10780)(MIC=128 μg/ml), Staphylococcus xylosus (BCRC 12930)(MIC=64 μg/ml), Staphylococcus aureus (BCRC 10781)(MIC=128 μg/ml), Listeria monocytogenes (BCRC 14845)(MIC=128 μg/ml), Streptococcus bovis (BCRC 14729)(MIC=128 μg/ml), Streptococcus iniae (laboratory strain)(MIC=128 μg/ml), Lactococcus garvieae (laboratory strain)(MIC=256 μg/ml);
      • Gram-negative bacteria : Klebsiella oxytoca (BCRC 13985)(MIC=128 μg/ml), Pseudomonas aeruginosa (BCRC 10944)(MIC=64 μg/ml), Escherichia coli (BCRC 10675)(MIC=64 μg/ml), Enterobacter aerogenes (BCRC 10370)(MIC=64 μg/ml), Enterobacter cloacae (BCRC 10401)(MIC=64 μg/ml), Yersinia enterocolitica (BCRC 13999)(MIC=256 μg/ml)

    • Hemolytic Activity

      • [Ref.18586467] MHC=8 μM against human red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21192 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21192.

Physicochemical Information

    • Formula

    • C131H180N26O28

    • Absent Amino Acids

    • CDEHLMPQRSTV

    • Common Amino Acids

    • Y

    • Mass

    • 2567.03

    • PI

    • 9.63

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +4

    • Boman Index

    • -324

    • Hydrophobicity

    • -0.325

    • Aliphatic Index

    • 73.5

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 14440

    • Absorbance 280nm

    • 760

    • Polar Residues

    • 8

DRAMP21192

DRAMP21192 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria

Literature Information

  • ·Literature 1

    • Title

    • Design and synthesis of cationic antimicrobial peptides with improved activity and selectivity against Vibrio spp.

    • Reference

    • Int J Antimicrob Agents. 2008 Aug;32(2):130-8. doi: 10.1016/j.ijantimicag.2008.04.003.

    • Author

    • Chou HT, Kuo TY, Chiang JC, Pei MJ, Yang WT, Yu HC, Lin SB, Chen WJ